ResourceSeparations

Efficient LC-MS/MS Method for Determination of Δ<sup>9</sup>-Tetrahydrocannabinol in Human Plasma with Excellent Selectivity and Sensitivity

14 May 2014

This poster presents the uses of C18 stationary phase silica and the results obtained with this new method developed in our laboratories for the determination of Δ9-Tetrahydrocannabinol and its metabolites in plasma using LC-MS/MS analysis.

Solid Phase Extraction Products (SPE cartridges & Well Plates) – SiliaPrep™ & SiliaPrepX™

SiliCycle Inc.

Solid Phase Extraction (SPE) is the basis of analytical laboratories. A crucial step of this process is sample preparation. Therefore we know that a clean sample will yield better results. To achieve this goal SiliCycle has designed SiliaPrep, which is a silica based sorbent exempt of fines, and SiliaPrepX, polymeric based sorbent, that can be found in cartridges, well plates and SPME (Solid Phase Micro-Extraction) cartridges formats.By using SiliCycle’s sample preparation solutions, you will generate ultra pure samples, reduce your number of false positives in your screenings and which will provide you with high quality data that were easily achieved, on the first time. And with tools such as SiliCycle’s Vacuum Manifolds, which are designed to help you achieve a next step of productivity in your research, you cannot fail. Trying them is the first step to achieve greater results.Choose from a Wide Variety of Phases: Polar Non-polar Ion exchange Mixed-mode or any specialty phases And from a Selection of Sorbents for Greater Results with: Human and animal biological fluids Waste water Petrochemical residues Toxic residues Food and beverage

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UHPLC and HPLCHigh performance liquid chromatography (HPLC) and ultra high performance liquid chromatography (UHPLC), also known as UPLC, are analytical techniques used to separate, identify and quantitate components of complex mixtures including biological samples such as proteins and lipids as well as chemical mixtures of pesticides, drugs and oils. Both techniques are liquid chromatographic methods but differ by operating pressures (HPLC < 6000 psi < UHPLC ). Components of HPLC and UHPLC systems include columns, detectors, pumps, autosamplers and column heaters. Explore a range of UHPLC and HPLC columns for your specific sample needs including reverse phase, normal phase, ion exchange, HILIC, ion exclusion and size exclusion columns. For more specialized HPLC, explore FPLC, countercurrent LC and simulated moving bed systems. Find the best UHPLC and HPLC equipment in our peer reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Drugs of AbuseA drug of abuse is a drug that has been taken for non-medical purposes. Such drugs can have mind-altering effects, with some causing dependence and addiction.Human PlasmaHuman plasma is the liquid component of blood, which carries blood components - nutrients, hormones, proteins, and waste - throughout the body. Plasma-based studies provide insights into biomarkers, immune responses, and disease mechanisms. Compare plasma handling tools and systems in our peer-reviewed product directory.
Efficient LC-MS/MS Method for Determination of Δ<sup>9</sup>-Tetrahydrocannabinol in Human Plasma with Excellent Selectivity and Sensitivity