SelectScience
Join Free
ResourceSeparations

Application of Differential Ion Mobility Mass Spectrometry to Peptide Quantitation

SCIEX
26 Jun 2014

This application note presents two case studies that evaluate the SelexION™ Differential Mobility Separation Device for the quantitation of therapeutic peptides. Selectivity, sensitivity and precision of peptide measurements obtained in experiments with and without DMS were compared.

Related products

Request Quote for All Products

SelexION differential mobility spectrometry

SCIEX

SelexION differential mobility spectrometry is an effective ion mobility spectrometry tool for improving data quality in the quantitation and characterization of challenging samples requiring advanced analytical selectivity. SelexION on the SCIEX 5500+ series and 6500+ series delivers a new dimension of selectivity and performance for applications requiring the separation of isobaric species, elimination of challenging co-eluting contaminants, and reduction of high background noise.

(2)

Triple Quad 5500+ system

SCIEX

The Triple Quad 5500+ system is designed to conquer your laboratory’s most complex workflows and opportunities. This LC-MS/MS system promises to provide the sensitivity and performance to meet analytical and regulatory demands for low-level trace detection with ease.

(15)

Links

SCIEXCompany website

Tags

LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.PeptidesPeptides are short chains of amino acids that play key roles in biological processes, including signaling, immune responses, and enzyme regulation. Peptide research is critical in drug discovery, diagnostics, and vaccine development. Browse our peer-reviewed product directory to find the best peptides and peptide-related products, compare options, check reviews, and get pricing directly from manufacturers.TherapeuticsTherapeutics are treatments designed to alleviate or cure diseases. These include pharmaceuticals, biologics, and gene therapies, which work by targeting specific disease mechanisms. Advances in personalized medicine and biologics offer new hope for patients with conditions that were previously difficult to treat. Browse our peer-reviewed product directory to find therapeutic solutions for various diseases; compare products, check user reviews, and get pricing directly from manufacturers.

Related resources