ResourceSeparations

Application of Differential Ion Mobility Mass Spectrometry to Peptide Quantitation

26 Jun 2014

This application note presents two case studies that evaluate the SelexION™ Differential Mobility Separation Device for the quantitation of therapeutic peptides. Selectivity, sensitivity and precision of peptide measurements obtained in experiments with and without DMS were compared.

SelexION differential mobility spectrometry

SCIEX

SelexION differential mobility spectrometry is an effective ion mobility spectrometry tool for improving data quality in the quantitation and characterization of challenging samples requiring advanced analytical selectivity. SelexION on the SCIEX 5500+ series and 6500+ series delivers a new dimension of selectivity and performance for applications requiring the separation of isobaric species, elimination of challenging co-eluting contaminants, and reduction of high background noise.

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Triple Quad 5500+ system

SCIEX

The Triple Quad 5500+ system is designed to conquer your laboratory’s most complex workflows and opportunities. This LC-MS/MS system promises to provide the sensitivity and performance to meet analytical and regulatory demands for low-level trace detection with ease.

(15)

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Application of Differential Ion Mobility Mass Spectrometry to Peptide Quantitation