Application Note: SEC-MALS method for characterizing mRNA biophysical attributes
31 March 2020

In this application note, Wyatt Technology describes a SEC-MALS method, incorporating DAWN and Optilab detectors, that aims to quantify a number of biophysical attributes of mRNA. This method is designed to provide a convenient, quick, and powerful tool for characterizing  mRNA molecules and can also be used to study the effects of different ions, ionic strength, pH, and other buffer conditions on mRNA biophysical properties and stability.