3D bone marrow niche: Scalable and physiologically relevant ex vivo drug screening platform for acute myeloid leukemia and multiple myeloma

Crown Bioscience presents a robust 3D Bone Marrow Niche (BMN) platform that enables medium-throughput, physiologically relevant drug screening for hematologic malignancies. By co-culturing primary AML and MM patient cells with endothelial and mesenchymal stromal cells in a protein-rich hydrogel, this model closely mimics the human bone marrow environment to evaluate drug efficacy and off-target effects.