Application Note: Microfluidics and live-cell imaging
1 October 2020
Researchers have been devising ways to grow cells in culture in controlled laboratory conditions since the late 1800s, and a staggering array of culture methods has been developed in the intervening years. Microfluidic devices are being used to create more in vivo-like systems by controlling the microenvironment (e.g., cell matrix, atmosphere, flow rate, chemical gradients, pH, temperature). This control is more easily achieved and maintained in microfluidic devices compared to traditional instruments. As a result, microfluidic technologies for cell-based assays have the potential to increase the biological relevance of cell models while maintaining or increasing the throughput of current methods.