Development of human iPSC-derived hepatocytes for drug discovery, translational research and toxicity testing

Hepatocytes are responsible for the primary functions of the liver, including detoxification and xenobiotic metabolism, making them essential for in vitro toxicology. However, researchers often face challenges surrounding their scarcity, variability and physiological relevance of immortalized cell lines, which in turn, hinders the ability to effectively predict drug-induced liver injury (DILI).

Explore the power of opti-ox™, a deterministic cell programming technology, that can generate consistent, scalable, hiPSC-derived hepatocytes, termed ioHepatocytes. Discover how these ioHepatocytes perform critical hepatocyte functions, show expression of genes involved in phase I, II and III of drug metabolism, and have functional cytochrome P450 enzymes making them highly suitable for toxicology, research and disease modeling.