Animal Models Products & Reviews

The Indus Doppler Flow Velocity System is a high-frequency, real-time pulsed Doppler measurement device with integrated data analysis software designed for measuring cardiovascular function in small animals.

The iNSiGHT DXA system is an in vivo Dual Energy X-Ray Absorptiometry (DXA/DEXA) technology for preclinical research. This fully shielded X-ray cabinet is suitable for small animal DXA applications – mice, rats, and animals of similar size (up to 5kg). Efficient body composition measurements allow for fast scan times of 25 seconds. Combined with its low-dose radiation, it’s ideal for longitudinal studies.

The Indus Rodent Surgical Monitor+ is an advanced, integrated surgical warming and vital signs monitoring solution for preclinical research in mice, rats and other small animals. The system provides detailed information, in real time, regarding subject body temperature, ECG, heart rate, pressure and respiration. 

This immunodeficient nude mouse originated from NIH and was originally thought to be a BALB/c congenic. It was later determined that it was not inbred and is therefore maintained as an outbred. It is not associated with any stock or strain. The animal lacks a thymus, is unable to produce T cells, and is therefore immunodeficient. To Charles River from NCI in 2010. Model Properties: Coat Color: Hairless, albino background…

The PhysioTel F20-EET and F40-EET transmitters are designed primarily for sleep research applications in rodents. These transmitters will allow simultaneous monitoring of two biopotential channels, such as EEG and EMG, temperature, and locomotor activity. The biopotential electrode has an outer diameter of .3mm making the lead an ideal size for use in EEG applications in small animals. 

FinePointe Resistance and Compliance

You can build custom chamber configurations using any of the rat package designs to meet virtually any research requirement. Additional items to consider include an audio generator, infusion pump, scrambled foot aversive stimulation, lickometer, movement detector, and constant current square wave stimulator. Each operant package is a complete single test station including the SmartCtrl™ interface. Note: Packages do not includ…

Resolvins are a family of potent lipid mediators derived from both eicosapentaenoic acid (EPA; Item No. 90110) and docosahexaenoic acid (DHA; Item No. 90310). In addition to being anti-inflammatory, resolvins promote the resolution of the inflammatory response back to a non-inflamed state. Resolvin D1 (RvD1) is produced physiologically from the sequential oxygenation of DHA by 15- and 5-lipoxygenase. A 17(R)-epimer (Item No. 1…

BioIVT has 30+ tissue types available by species in a variety of formats to meet your research needs.

The Prospect T1 is an innovative high-frequency ultrasound system designed specifically for in vivo preclinical imaging in small animals such as mice and rats. This compact and cost-effective tablet-based system provides high-resolution images (up to 30 µm) and advanced capabilities to monitor changes in hemodynamics and observe anatomical structures in real-time.

In vivo model for cardiovascular, alzheimer’s and other neurodegeneration studies. Apolipoprotein E (ApoE) is a critical apoprotein of the chylomicron which binds to a specific receptor on liver cells and peripheral cells. Defects in ApoE result in disrupted transportation of lipoproteins, fat-soluble vitamins and cholesterol into the lymph systems, and then into blood.ApoE Knockout Rat Characteristics: 16 bp deletion wit…

3D Live Cell Perfusion Culture System

The CD34 humanized NSG-FLT3-IL15 (F15) mouse is the most comprehensive immune cell mouse model from the Jackson Laboratory to date.

Take advantage of our large inventories of common inbred strains and the convenience of having your breeding and drug efficacy needs met by the leading experts in mouse modeling.

Accelerate oncology drug development with Crown Bioscience’s PDX Mouse Clinical Trials. Leverage the world’s largest clinically relevant PDX collection to model patient tumor heterogeneity, predict clinical outcomes, discover biomarkers, and optimize drug strategies. Improve clinical translation and reduce attrition with highly predictive, patient-relevant insights.

Dextran sulfate sodium salt, or DSS, is a synthetic sulfated branched polysaccharide derivative of dextran that has multiple uses in biomedical and clinical research. One important property of DSS is to triggers colitis in mice and rats when administered in drinking water.  

The Prospect T2 is an innovative high-frequency ultrasound system designed specifically for in vivo preclinical imaging in small animals such as mice and rats. This compact and cost-effective tablet-based system provides high-resolution images (up to 30 µm) and advanced capabilities to monitor changes in hemodynamics and observe anatomical structures in real-time.

Wire myography is an in vitro technique that allows us to examine functional responses and vascular reactivity of isolated small resistance arteries. Vessels from various species, including transgenic models, and vascular beds can be examined in a variety of pathological disease states. Vessels are dissected, cleaned, and then mounted onto a channel myograph under isometric techniques. Each vessel is then normalized to determi…

Pressure arteriography is the gold-standard for quantifying function, reactivity and mechanics in isolated perfused blood vessels. When embarking on pressure arteriography, many factors warrant consideration. In addition to the requisite surgical skills for isolating and cannulating small arteries, proper instrumentation is also paramount.

The M-Series™ systems are cryogen/cooling-free, self-shielded, high-performance MRI systems based on permanent magnet technology. The M-Series systems allow preclinical researchers, with or without in-depth knowledge of MR physics, to utilize the gold standard method in soft tissue imaging without the cost, complexity, and technical burden of superconducting MRI systems. 

The NEWTON FT-900 is a deeply cooled CCD imager dedicated to SWIR (NIR-I, NIR-II), fluorescence and bioluminescence multi-spectral imaging as it allows for in vivo applications in the visible, near and short-wave infrared spectrum (VIS/ NIR/ NIR-II). Smart and ultra sensitive, it provides non-ionizing and non-invasive visualization of biological processes in real-time.

The TriTom imaging platform utilizes photoacoustic and fluorescence tomographies (PAFT) for high-resolution, non-invasive whole-body imaging in small animal models, achieving up to 160 µm resolution. This multi-modality system enables simultaneous acquisition of photoacoustic and fluorescence data in large volumes (> 25 cm3), allowing for spectroscopic molecular analysis. 

The SuperArgus PET/CT is a high-performance imaging system it can be configured as a combined PET/CT or PET or CT only system, and features state-of-the-art phoswich PET detectors with true depth-of-interaction (tDOI) for resolution uniformity and high sensitivity. The system offers real-time imaging up to 2.5msec frame rate and advanced capabilities like sensorless cardiac gating and conscious/awake imaging.

The Newton 7.0 is a cutting-edge optical imaging system that offers the versatility to perform bioluminescence, fluorescence, and 3D tomographic imaging in a single device. Its user-friendly interface and advanced features make it ideal for in vivo, ex vivo, and in vitro imaging applications, as well as simultaneous imaging of multiple specimens.

The 11BHSD2 mouse was produced by injection of a construct, containing 11β-HSD2 cDNA isolated from mouse kidney and cloned into plasmid Clone 26 to recruit the 5.4 kb mouse α–myosin heavy chain (α-MHC) promoter, into pronuclei of C57BL/6 embryos. Transgenic mice were maintained by sibling mating and used as hemizygotes. Model Properties: Coat Color: Black Ideal For: Cardiac hypertrophy, heart failure Strain Code: 510 HE,…