Master the balancing act of biologic formulation development with Uncle
25 Oct 2022

Problem

Part of the development of a biologic drug is finding a formulation that optimizes its stability. Two key protein stability parameters are melting and aggregation temperature, Tm and Tagg. To effectively screen many different formulations with the goals of ranking and refining them, you need a tool that keeps tabs on many stability parameters of many samples all at once.

Solution

Uncle is the original all-in-one platform that characterizes stability of biologics in high throughput with only 9 µL of sample. It allows you to follow melting and aggregation of the protein simultaneously and to use the data to rank and rate formulation excipients for their influence on the behavior of the analyte.

Proof

In this webinar, we’ll present a case study on Eurofins’ formulation development of a fusion protein. We screened different excipients for their influence on stability to find an optimized formulation that balances thermal stability and minimizes the tendency of the analyte to aggregate.

Key learning objectives

  • Use fluorescence and static light scattering to assess protein stability (unfolding & aggregation)
  • Develop, screen and improve formulations to optimize protein stability
  • Increase efficiency in development of biologics
  • Flexible multi parameter stability testing

Who should attend?

  • Protein Scientists
  • Formulation Scientists
  • Lab Managers
  • Research Directors

Certificate of attendance

All webinar participants can request a certificate of attendance, including a learning outcomes summary, for continuing education purposes.

Unchained Labs