TechTalk: GLP-1 & GIP under the lens: HRMS strategies for synthetic peptide profiling

Friday, September 11 at 15:00 BST | 16:00 CEST | 10:00 EDT | 07:00 PDT

Synthetic peptides like GLP-1 analogs (e.g., semaglutide, tirzepatide) present analytical challenges due to complex modifications and potential degradation products. High resolution accurate mass spectrometry (HRMS) offers the sensitivity, resolution, and mass accuracy needed for confident sequence confirmation and impurity profiling.

In this Tech Talk, attendees will discover how integrated workflows from high-throughput screening using the INTACT Mass App to detailed degradation characterization with UNIFI streamline synthetic peptide analysis, support quality attribute monitoring, and ensure regulatory compliance.

Certificate of attendance
If you attend the live TechTalk, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes. If you view the on-demand TechTalk, you can request a certificate of attendance by emailing editor@selectscience.net.

TechTalk details

  • Cost: Free to attend
  • Location: Online
  • Duration: 20 minutes

Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on-demand recording once it becomes available.

Speakers

Jonathan Fox
Speaker
Biologics Consulting Scientist, Waters Corporation
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Who should attend?

This event is perfect for:
  • Bioanalytical scientists
  • Pharmaceutical R&D researchers
  • QC/QA laboratory managers
  • Contract Research Organisation (CRO) scientists
  • Mass spectrometry specialists

Alliance iS HPLC System

Waters

Designed to meet the everyday challenges facing pharmaceutical quality control (QC) labs, the Alliance™ iS HPLC System delivers a new era of intuitive simplicity by reducing errors with innovative system intelligence, enhancing productivity with safeguards to ensure system performance, and maximizing system uptime. 

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ACQUITY UPLC System

Waters

Waters ACQUITY UPLC - Dramatic Improvements in Speed, Sensitivity and Resolution Whether you work in methods development or quality assurance, in drug discovery and development or testing for safety in food supplies, you seek a productivity edge. With the ACQUITY UPLC® System, now you can get more information in a single, short run than you've ever seen with HPLC. Waters ACQUITY UPLC System UltraPerformance LC® (UPLC®) technology starts with unique 1.7 μm small-particle chemistries. Chromatographers no longer need to choose between speed and resolution–with UPLC you get both. Instrument Designed for Chemistry; Chemistry Designed for the Instrument The ACQUITY UPLC System has been holistically designed to match the performance needs of our innovative column chemistries with robust hardware, easy-to-use software and specialized support services. Small, pressure-tolerant particles High-pressure fluidic modules Minimized system volume Negligible carryover Reduced cycle times Fast response detectors Integrated system software and diagnostics With UPLC you have the ability to work more efficiently with higher speed, sensitivity and resolution at a much wider range of linear velocities, flow rates and backpressures to obtain superior results. The Waters ACQUITY UPLC System's high-pressure fluidics optimizes flow rates to make the most of small particle technology. The ACQUITY UPLC System's sample-handling design is designed to ensure exceptionally low carryover and reduced cycle time. And when interfaced with the Sample Organizer, it increases unattended sample capacity by ten times. High-speed detectors, both optical and mass, contribute to increased sensitivity and help manage the heightened speed and resolution requirements of UPLC. ACQUITY UPLC Systems are easily controlled, diagnosed, and monitored via a graphical system console interface. The console offers: Quick and easy access to critical instrument parameters Simple system start-up, elegant system status monitoring and predictive performance indicators to ensure maximum productivity Data management capabilities that are supported by both MassLynx™ and Empower™ software The ACQUITY UPLC System is also supported by Intelligent Device Management technology with our Connections® INSIGHT™ service, providing instrument diagnostics.

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What will this webinar cover?

  • The advantages of high resolution accurate mass spectrometry (HRMS) over nominal mass systems for resolving near-isobaric impurities and peptide variants.
  • How high-throughput screening tools enable rapid mass confirmation, sequence verification, and routine purity reporting.
  • Strategies for comprehensive qualitative analysis and tracking of forced degradation products.

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