TechTalk: Advancing cell-free protein engineering workflows by translating enzyme variants into function

Monday, February 2 at 15:00 GMT | 16:00 CET | 10:00 EST | 7:00 PST

Traditional protein engineering is often constrained by iterative cycles, fragmented workflows, and limited reproducibility.

In this 20-minute TechTalk, Ribbon Bio will showcase a validated, fully cell-free design-build-test-learn (DBTL) workflow enabling one-shot optimization of a DNA-modifying enzyme. Based on a collaborative case study with Scala Biodesign and Nuclera, the session will illustrate how computational design, high-accuracy synthetic DNA, and rapid cell-free expression can be tightly integrated to deliver enzyme variants with superior biochemical performance.

Attendees will learn how linking expression metrics with functional readouts supports data-driven decisions, reduces development risk, and accelerates enzyme engineering for biocatalysis and synthetic biology.

Key learning objectives

• Understand how a fully cell-free, integrated design–build–test–learn (DBTL) workflow enables one-shot protein engineering without iterative optimization cycles.
• Learn how to translate computationally designed enzyme variants into reproducible expression and functional performance at application-relevant scale.
• Gain insight into linking expression metrics with biochemical and functional readouts to objectively assess and de-risk protein engineering campaigns.
• Evaluate how cross-platform integration (design, DNA synthesis, and expression) accelerates enzyme optimization for biocatalysis and synthetic biology applications.
  

Who should attend?

• Scientists and engineers working in enzyme engineering, synthetic biology, and biocatalysis
• R&D leaders working in pharma, biotech, and industrial biotech exploring rapid protein optimization
• Researchers working on DNA-binding proteins, transcription factors, or enzyme characterization
• Business development and innovation managers seeking strategic technology collaborations in the design–make–test space

Certificate of attendance
If you attend the live TechTalk, you will automatically receive a certificate of attendance, including a learning outcomes summary, for continuing education purposes.

If you view the on-demand TechTalk, you can request a certificate of attendance by emailing editor@selectscience.net.

TechTalk details

• Cost: Free to attend
• Location: Online
• Duration: 20 minutes

Registration is required to secure your place. If you register but can’t attend live, you will receive a link to the on‑demand recording once it becomes available