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The future of oligonucleotides in medicine

Shimadzu Corporation
20 May 2025
The future of oligonucleotides in medicine

ATDBio has been at the forefront of supporting COVID-19 diagnostics through the production of high-quality DNA and RNA primers. With deep expertise in nucleic acid chemistry, ATDBio has rapidly scaled its operations to meet global testing demands with the support of Shimadzu.

Hear from Asha Brown and Tom Brown from ATDBio as they share the chromatography techniques they use to enhance purification of oligonucleotides and learn how Shimadzu LC systems have provided them with the flexibility to synthesize oligonucleotides on both small and large scales.

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Shimadzu Corporation

Shimadzu Corporation was founded in Kyoto, Japan in 1875 and has been supplying cutting-edge analytical and measuring instruments for a broad range of applications for over 150 years. Key markets include pharmaceuticals, life sciences, food & beverages, chemicals, petrochemicals, environmental, material science, and forensics/toxicology. Products include chromatographs (HPLC/UHPLC/SFC, GC), mass spectrometers (GC-MS/MS, LC-MS/MS, MALDI, ICP-MS), spectrophotometers (FT-IR, Fluorescence, UV-VIS-NIR), atomic spectrometers (AA, ICP), X-ray spectrometers (ED-XRF, XRD, XRF), thermal analyzers, Total Organic Carbon (TOC) analyzers, particle size analyzers, material testing machines, and balances, etc.

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DNA / RNA Extraction and PurificationPurified DNA and RNA are required for numerous downstream molecular biology applications. Consequently, the importance of high-quality DNA/RNA extraction and purification equipment cannot be underestimated. Many purification kits are available and are typically optimized for nucleic acid type and source, including plasmid DNA, genomic DNA, mRNA, RNA and viral nucleic acid purification kits. Automated extraction and purification of nucleic acids can be implemented with magnetic bead separator instruments or high-throughput purification workstations. Find the best DNA/RNA extraction and purification equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.OligonucleotidesOligonucleotides are small nucleic acid polymers, usually less than 20 bases in length. Oligonucleotides can be made via enzymatic cleavage or more commonly by chemical synthesis with polymerases. Their use includes FISH, southern blots, microarrays and as primers in PCR. High fidelity synthesis kits and detection systems are available for easy production and detection, respectively.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.Vaccine DevelopmentVaccine development focuses on creating immunizations to protect against infectious diseases. The process involves identifying antigens, developing and testing vaccine efficacy, and ensuring safety through preclinical testing and multiple clinical trial phases. Scientists use various approaches, including weakened or inactivated viruses, protein subunits, or mRNA. Advanced platforms and rapid diagnostic tools aid in vaccine research and testing. Explore vaccine development solutions in our peer-reviewed product directory; compare products, read reviews, and get pricing directly from manufacturers. Covid-19COVID-19, caused by the SARS-CoV-2 virus, has led to a global health crisis with profound impacts on societies and economies. Research into diagnostics, vaccines, treatments, and understanding viral mechanisms continues to evolve. The pandemic has accelerated innovations in healthcare and biopharmaceuticals, including novel vaccine platforms and rapid testing technologies. Browse our peer-reviewed product directory to find top COVID-19 testing kits, research tools, vaccines, and treatments, compare products, read reviews, and receive direct pricing from manufacturers.

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