Discover the Latest in Metabolite Analysis

New Products, Videos and Application Notes

17 Jun 2015
Lois Manton-O'Byrne, PhD
Executive Editor

Discover new products, videos and application notes in this exclusive round-up

1. INDUSTRY NEWS: SCIEX and Hepregen Announce Co-Marketing Agreement for Comprehensive Metabolite Identification Solution
SCIEX and Hepregen Corporation have announced a Co-Marketing Agreement to deliver a new metabolite identification (Met ID) solution for drug metabolism scientists. This solution provides an extensive view into in vitro data to enable researchers to generate, identify and analyze metabolites in one simple workflow. More information

2. VIDEO: The Vion IMS QTof Mass Spectrometer from Waters
In this video, learn more about the Vion™ IMS Q-Tof™ Mass Spectrometer from Waters. This mass spectrometer brings high-resolution tandem mass spectrometry and ion mobility separation to routine analyses, making it ideal for metabolite identification. Watch video

3. NEW PRODUCT: New-Generation System from Thermo Fisher Scientific Redefines Performance for GC-MS Applications
The new Thermo Scientific Q Exactive GC hybrid quadrupole-Orbitrap GC-MS/MS instrument represents the first-ever commercial system offering a combination of gas chromatography and HRAM Orbitrap mass spectrometry. It offers scientists fast, predictable GC separations and an increased ability to profile entire metabolomes. More information

4. APPLICATION NOTE: Novel Bioluminescent Cell Metabolism Assays Integration with HP D300 Digital Dispenser and Tecan Gas Controlled Module Equipped Infinite M200 Pro Reader
This application note describes the integration of Tecan/Hewlett Packard instrumentation capabilities with two of Promega’s recently developed assays targeting cell metabolism applications, the Bioluminescence Live Cell Viability Assay and the NAD(P)/NAD(P)H Detection Assays. Download application note

5. APPLICATION NOTE: Interrogating Gynecological Cancer Cell Metabolisms at Different Oxygen Tensions: Results Using a Novel Modified Atmosphere Handling System
This poster illustrates a method for the metabolic profiling of gynecological cancer cell lines using a Seahorse Bioscience XFe96 Extracellular Flux Analyzer and a novel workstation from Don Whitley Scientific, which enables analysis to be performed under hypoxic conditions, as well as air. Download poster

6. APPLICATION NOTE: Use of Perfused 3D Models for Cytotoxicity and Metabolism Studies
This poster illustrates a method for the metabolic profiling of gynecological cancer cell lines using a Seahorse Bioscience XFe96 Extracellular Flux Analyzer and a novel workstation from Don Whitley Scientific, which enables analysis to be performed under hypoxic conditions, as well as air. Download poster

7. APPLICATION NOTE: Metabolic Phenotyping Using Atmospheric Pressure Gas Chromatography-MS
This application note reports an APGC-TOF MSE profiling approach and its application to metabolic fingerprinting of Arabidopsis using the Waters SYNAPT® G2-S HDMS® Mass Spectrometer and APGC System. Atmospheric pressure GC (APGC) is a soft chemical ionization technique that generates a mass spectrum, in which there is minimal fragmentation and conservation of the molecular ion. Download application note

8. VIDEO: Metabolomic Analysis of Skin Lesions for Melanoma by Mass Spectrometry
In this video, Michael Costanzo, a Research Assistant at the University of Florida, summarizes a presentation about research into metabolomic analysis of skin lesions for melanoma by mass spectrometry. Along with his co-authors, the team shared their research involving the discovery of biological markers at the earliest possible stage of cancer progression. Learn how the accurate mass capabilities of the Thermo Scientific Orbitrap can improve the identification of metabolomic biomarkers. Watch video

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Thermo Scientific™ Q Exactive™ GC Orbitrap™ GC-MS/MS System

Thermo Fisher Scientific

The Thermo Scientific™ Q Exactive™ GC system is the first-ever combination of high resolution gas chromatography with high-resolution/accurate-mass (HR/AM) Orbitrap detection for the most comprehensive sample characterization. This easy-to-use system provides the most comprehensive characterization of samples in a single analysis for the highest confidence in compound discovery, identification, and quantitation. Building upon the flexible modularity of the Thermo Scientific™ TRACE™ 1300 Series GC, including user-exchangeable injectors and detectors, the Q Exactive GC system has the quantitative power of a GC triple quadrupole MS combined with the high precision, full scan high-resolution/accurate-mass capability that only Orbitrap technology can offer.   Key Features: Advanced quadrupole technology (AQT) for high transmission of selected masses Resolving power up to 120,000 at m/z 200 Part-per-trillion-level sensitivity Thermo Scientific™ Extractabrite™ ion source for robust, rugged electron impact (EI) and chemical ionization (CI) performance Curved linear C-trap for precise ion injection HCD collision cell for higher energy collisional dissociation provides MS/MS ion characterization Intelligent identification software elucidates the nature of each injected sample. Applications: Untargeted and targeted metabolomics Food and beverage Industrial analyses Environmental Pharmaceutical Clinical and toxicology

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Vion IMS QTof

Waters

Vion IMS QTof is a high resolution QTof mass spectrometer that delivers the selectivity of ion mobility to every scientist, for every analysis. Does high resolution, accurate mass data always lead to the correct answer first time? Avoid additional confirmatory experiments by utilizing the selectivity of ion mobility. Featuring new geometry and including XS Ion Optics and the QuanTof2 detection system, the Vion IMS QTof  has the sensitivity and dynamic range to make ion mobility quantitative and routinely usable, enabling: Easier data interpretation as ion mobility cleans up and simplifies every spectrum Confident identification and quantification of analytes Faster method development and higher sample throughput Greater selectivity than conventional MS/MS with HDMSE With Vion IMS QTof you can use the selectivity of ion mobility to quickly refine spectra and discount chromatographically co-eluting compounds and background interferences. Enabling you to characterize your compounds with confidence. The ability to gather and process CCS data for every ion gives you more confidence in your data than ever before. Vion IMS QTof is driven by UNIFI scientific information system to deliver the most comprehensive analytical workflow, enabling you to target, identify, and review results in a single software platform. Make more informed decisions, faster. CCS provides chromatographic retention time independent data points, enabling confident identification of your analytes and reducing the risk of false positives and false negatives. Even during initial sample analysis, without any retention time knowledge, you can use theoretical exact mass and CCS library values to identify unknown and unexpected components. Applications: Screening - Meeting legislative and regulatory demands requires the utmost confidence in your data. UNIFI informatics workflows integrate the value of CCS, reducing false positives and false negatives driving laboratory efficiency. Pharma - The combination of UNIFI and Vion IMS QTof brings ion mobility to your drug discovery experiments while maintaing ease and efficiency you need for your routine Met ID processes. Omics - A recurring challenge for omics studies is the identification and structural elucidation of metabolites, lipids, and peptides of interest. Incorporating Vion IMS QTof into your workflow gives you not only CSS data from every component, but also increase analytical space and resolution.

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MALDI SYNAPT G2-Si High Definition Mass Spectrometry

Waters

Redefining Resolution - Resolution in 3 Dimensions. MALDI SYNAPT G2-Si is a uniquely powerful and versatile MS platform. It's the only way to combine multiple dimensions of separation for analysis of complex samples, from imaging to biological research to chemical materials characterization. The MALDI SYNAPT G2-Si gives you high performance, accurate mass MALDI MS/MS, superior post-ionization separation with T-Wave IMS, High Definition Imaging (HDI) MALDI workflows, versatile experimental options, and the ultimate UPLC/MS/MS performance.

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