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What type of ultrapure water should I use for HPLC (UHPLC) analysis?

24 Sept 2026

As ‘HPLC-grade water’ becomes a commonly used standard throughout analytical laboratories, selecting a water purification system that can provide the right volume and quality of HPLC-grade water is essential. This resource provides guidance on selecting and using ultrapure water for HPLC and UHPLC analysis, emphasizing the importance of water quality in achieving reliable and reproducible results. It outlines key water contaminants that can affect analytical performance, describes the required properties of HPLC-grade water, and details advanced purification technologies and system features necessary to consistently produce high-quality water for laboratory applications.

Resource details:

Resource type: Application note
Page count: 4
Read time: 5 mins

Genie G Ultrapure Water System

RephiLe Bioscience Ltd.

Genie G Ultrapure Water System produces ultrapure water (Type I water) and EDI water (Type II water) from tap water directly. This high-end water system integrates IoT technology with advanced water purification techniques. Its optimized flow path design, combined with comprehensive process monitoring, ensures stable and reliable water quality. The system is CE/RoHS certified. RephiLe provides full documentation to support user’s GMP, GSP, GAP, GCP, GLP requirements.

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Ultrapure WaterUltrapure water is the highest purity water and contains the lowest levels of organic and inorganic contaminants, particulates and microorganisms.HPLCHigh-performance liquid chromatography (HPLC) is a technique for separating, identifying, and quantifying components in mixtures. It is widely used in chemical, pharmaceutical, and environmental analysis to ensure purity and identify unknown compounds. Explore the best HPLC systems in our peer-reviewed product directory; compare products, read reviews, and get pricing directly from manufacturers.UHPLC