ResourceLife Sciences
Using humanized in vivo models for pre-clinical antibody development: A case study
15 Mar 2021The pre-clinical development of engineered antibodies presents unique challenges linked to their human-specific molecular functions.
Researchers at The Jackson Laboratory (JAX) have developed several humanized mouse models to test in vivo the different features of engineered antibodies. In this poster, the Jackson Laboratory (JAX) present Rituximab as an example of the use of JAX’s in vivo tools for the preclinical development of engineered antibodies.
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AntibodiesAntibodies are used in techniques such as confocal and fluorescence microscopy, flow cytometry, ELISA, ELISPOT, immunohistochemistry, western blotting and immunopreciptation. Select specific antigen reactivity, high specific affinity, low non-specific binding, monoclonal or polyclonal, primary or secondary antibodies and associated conjugates such as an enzyme or dye for visualization.Animal ModelsThe use of non-human animals in experiments or behavorial observations. The research is conducted inside universities, medical schools, pharmaceutical companies, farms, defence establishments, and commercial facilities that provide animal-testing services to industry. It includes pure research such as genetics, developmental biology, behavioral studies, as well as applied research such as pharmaceutical testing in pre-clinical, before human, studies. Engineered AntibodiesEngineered antibodies are modified to enhance specificity, stability, and functionality for therapeutic and diagnostic applications. These antibodies are central to immunotherapy and biomarker detection. Compare engineered antibody solutions in our directory to find top products and reviews.