Miniaturized thermal shift assay of β-lactoglobulin using PULSEspencer R and qTOWER iris 384
15 May 2026This application note demonstrates a miniaturized thermal shift assay (TSA) workflow for assessing protein stability using β‑lactoglobulin as a model system. By combining the PULSEspencer R for precise low‑volume dispensing with the qTOWER iris 384 for UV fluorescence detection, the study shows that reliable and reproducible TSAs can be performed at reduced reaction volumes.
Discover how this approach enables high‑throughput screening while minimizing sample and reagent consumption, without compromising data quality. The results confirm consistent melting temperature measurements across conditions, and highlight the suitability of this workflow for protein analytics and pharmaceutical development applications.
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qTOWER iris: The Real-Time PCR-Thermocycler
Analytik Jena GmbH+Co. KGNo matter where your journey takes you in the world of qPCR, this real-time PCR thermal cycler is ready for anything, giving you full control and freedom of choice - from consumables to assays to colour modules. The instrument is operating quietly, smoothly and delivers reliable results on six channels. The temperature and readout accuracy are unsurpassed. With this open system you are well equipped for all your projects.