Solid phase extraction of natural cannabinoids and metabolites from blood and urine

2 Aug 2022

In this application note, UCT, Inc. outlines two separate extraction methods for four natural cannabinoids and Δ9-THC metabolites from blood and urine using UCT's Clean Screen® THC and Styre Screen® HLB.

Styre Screen® Extraction Columns

UCT, Inc.

Styre Screen® Extraction Columns contain an ultra clean, highly cross-linked styrene and divinylbenzene copolymer. The Styre Screen particles have an average particle size of 30 microns and a very high analyte capacity making them ideal for standard solid phase extraction applications. The increased analyte capacity means that less sorbent bed mass is needed which results in faster flow rates and less solvent use. Higher throughput and less solvent waste disposal translate into significant savings in both time and money. In addition, no conditioning steps are required for most analyte applications.   Styre Screen® Extraction Columns Advantages:   Copolymer allows for extraction of acids, neutrals and bases High and reproducible recoveries Clean extractions Highly cross-linked styrene/divinylbenzene polymer Reduction in sorbent mass Faster flow rates pH stable (1 to 14) Reduction in solvent use High sorbent capacity Methods for NIDA/SAMHSA 5 Drugs

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Clean Screen® THC

UCT, Inc.

The CLEAN SCREEN® THC column is copolymerized on a rigid, purified silica gel support. The two functional groups include a reverse phase, and an ion exchanger, primary amine. This column is commonly used for analyzing THC and its metabolites. It has dual functionality for acids and hydrophobic compounds.

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Solid phase extraction of natural cannabinoids and metabolites from blood and urine