QCM-D Viscosity Analysis for Microlitre Protein Samples

This application note demonstrates how Q-Sense QCM-D instruments can be used to measure viscosity in microliter volumes. High concentration protein solutions are common in pharmaceutical applications. For example, solution formulation of monoclonal antibodies for therapeutic purposes often necessitates preparation of high concentration solutions of these proteins. Since high concentration solutions are expensive, sample volume is critical. QCM-D is a suitable tool for viscosity analysis of solutions, such as high concentration protein, where low sample volume and non-destructive analysis is preferable.