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QCM-D as a Powerful Real-Time Screening Tool for Protein Adsorption onto Glass and Plastic Surfaces
2 Feb 2017Plastic and glass materials are continuously used in protein biotechnology applications. Proteins have a tendency to passively adsorb to such surfaces via hydrophobic interactions, a phenomenon that has to be minimized or prevented in, for example, large-scale recombinant protein production. In such processes, extremely high protein concentrations, ranging from 40-100 mg/ml, are normally used. In this application note, QCM-D is used as a real-time screening tool for protein adsorption onto PVDF and borosilicate.
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Surface Area TestingPhysisorption studies fundamental parameters essential for the characterization of materials such as the specific surface area and pore size distribution. Properties such as porosity, strength, hardness, permeability, separation selectivity, corrosion, and thermal stress resistance can all be directly correlated to the porous structure of a material.ProfilometersProfilometers are instruments used to measure a surface's profile, in order to quantify etch depth, deposited film thickness, and surface roughness. They operate in either contact or non-contact modes and may use optical or stylus techniques to make the actual measurements.Protein InteractionsProtein interactions are essential for understanding cellular processes, as proteins work together to carry out biological functions. Studying protein interactions can provide insights into disease mechanisms, drug development, and cell signaling pathways. Explore the best tools for protein interaction research in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.BiotechnologyBiotechnology is the use of biological processes, organisms, or systems in the production of products and services. It spans a wide range of applications, including healthcare, agriculture, and environmental management. Browse our peer-reviewed product directory to find the best biotechnology tools, compare products, check reviews, and get pricing directly from manufacturers.Quartz Crystal Microbalance