Novel tools for spatial profiling of protein expression and glycosylation in brain pathology

Explore novel tools for spatial profiling of protein expression and glycosylation in brain pathology. This Vector Laboratories poster highlights an ultra-sensitive, multiplexed in situ approach combining reiterative staining with cleavable TSA fluorophores to enable high-plex protein and glycan co-detection in FFPE tissues. Learn how cleavable fluorescent probes (CFP) and HRP-mediated signal amplification support repeated cycles of staining, imaging, signal cleavage, and antibody/lectin stripping, while preserving tissue integrity and spatial resolution.

Discover how this workflow enables simultaneous analysis of 10+ protein and glycan markers at single-cell resolution, supports automation on advanced staining platforms, and facilitates glycosylation-focused biomarker discovery in Alzheimer’s disease, cancer, immunology, and infectious disease research.