ResourceLife Sciences
Non-Invasive Near-Infrared Fluorescence Imaging of Neutrophil Infiltration in a Mouse Model of Acute Lung Inflammation
15 Jun 2016This study evaluates the use of an activatable optical probe that is optically silent upon inhalation and produces a fluorescent signal only after selective cleavage by the serine protease elastase produced by neutrophils. The presence of bacterial endotoxin, lipopolysaccharide (LPS) in the lung can induce a major inflammatory response leading to acute lung injury. To monitor this, neutrophil infiltration into the lung can be measured by certain, activatable (smart) fluorescent probes.
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In Vivo Imaging Systems<i>In vivo</i> imaging systems, including pre-clinical imaging systems and medical imaging systems are used to non-invasively visualize and capture images of live animals and plants. Monitor the natural processes or diseases of your subjects using small-animal pre-clinical imaging systems, including single photon positron emission tomography (SPECT), positron emission tomography (PET), computed tomography (micro-CT), magnetic resonance imaging (MRI), X-ray radiography, ultrasound, fluorescence and bioluminescence imagers. Multimodal systems and software solutions are also available for correlative analysis of organ, tissue, cell, or molecular-level processes. Find the best in vivo imaging products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Animal ModelsThe use of non-human animals in experiments or behavorial observations. The research is conducted inside universities, medical schools, pharmaceutical companies, farms, defence establishments, and commercial facilities that provide animal-testing services to industry. It includes pure research such as genetics, developmental biology, behavioral studies, as well as applied research such as pharmaceutical testing in pre-clinical, before human, studies. Fluorescence Based AssayFluorescence based assays are widely used in life science research and high-throughput screening to measure a broad range of cellular activities.Small Animal ImagingSmall animal imaging is the visualization of living animals, most commonly mice and rats, for research purposes. This non-invasive technique is vital for long-term studies into drugs effects, as well as small animal anatomy and physiology.EndotoxinsNon-Invasive ImagingInflammatory DiseasesInfrared Imaging