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Mobile-Phase Cleanup Using Solid-Phase Extraction Disks

16 Jun 2011

In this comprehensive application note from 3M the authors describe a fast, simple procedure for purifying HPLC mobile phase using solid-phase extraction disks during the filtration step for mobile-phase preparation. The procedure tested was found to remove more than 95% of contaminants, and has been suggested as an effective and suitable solution for various gradient HPLC methods.

3M™ Empore™ SDB-XC 47 mm Disk

3M Bioanalytical

SDB-XC is a poly(styrenedivinylbenzene) copolymer used as a reversed phase sorbent for solid phase extraction.  SDB-XC is not bonded to silica but is a 100% copolymeric particle that is spherical, porous and cross-linked.  It does not exhibit the secondary cationic (silanol) interactions and pH limitations common to bonded silica sorbents, so it offers more predictable and reproducible reversed phase interaction.

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3M™ Empore™ SDB-XC 90 mm Disk

3M Bioanalytical

SDB-XC is a poly(styrenedivinylbenzene) copolymer used as a reversed phase sorbent for solid phase extraction.  SDB-XC is not bonded to silica but is a 100% copolymeric particle that is spherical, porous and cross-linked.  It does not exhibit the secondary cationic (silanol) interactions and pH limitations common to bonded silica sorbents, so it offers more predictable and reproducible reversed phase interaction.

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3M™ Empore™ SDB-XC 6ml Cartridge

3M Bioanalytical

SDB-XC is a poly(styrenedivinylbenzene) copolymer used as a reversed phase sorbent for solid phase extraction.  SDB-XC is not bonded to silica but is a 100% copolymeric particle that is spherical, porous and cross-linked.  It does not exhibit the secondary cationic (silanol) interactions and pH limitations common to bonded silica sorbents, so it offers more predictable and reproducible reversed phase interaction.

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Mobile-Phase Cleanup Using Solid-Phase Extraction Disks