MammaPrint and BluePrint in Early Breast Cancer: Clinical Implications of Prognostic Stratification and Molecular Subtyping

The BluePrint Molecular Subtyping Profile combined with the patient's MammaPrint test result, provides a greater level of clinical information to assist in therapeutic decision-making. BluePrint is an 80-gene expression signature which classifies breast cancer into Basal-type, Luminal-type and ERBB2-type cancers. An increasing body of evidence in the medical community suggests that breast cancer patients within these molecular subgroups have different prognoses with varied responses to specific therapies.

MammaPrint Provides Individualized Metastasis Risk Assessment for Your Breast Cancer Patients MammaPrint is the first FDA-cleared IVDMIA breast cancer recurrence assay. The unique 70-gene signature of MammaPrint provides you with the unprecedented ability to identify which early-stage breast cancer patients are at risk of distant recurrence following surgery, independent of Estrogen Receptor status and any prior treatment. Unlike previous generation genomic tests, MammaPrint interrogates all of the critical molecular pathways involved in the breast cancer metastatic cascade. It analyzes 70 critical genes that comprise a definitive gene expression signature and stratifies patients into two distinct groups — low risk or high risk of distant recurrence. With MammaPrint, there are no intermediate results. Hormonal therapy alone (e.g. Tamoxifen) may be sufficient to further reduce her risk if your patient is Low Risk by MammaPrint, when combined with traditional risk factors. Conversely, if she is High Risk by MammaPrint and has additional risk variables, more aggressive therapy including chemotherapy may be recommended. With MammaPrint, you gain vital insights into the aggressiveness of your patient’s tumor allowing you to tailor your treatment protocol to your patient’s individual needs.