ResourceSpectroscopy

Ligand Binding Mass Spectrometric Immunoassay (LB-MSIA™) Workflow with Deglycosylation for Therapeutic Antibodies

21 Aug 2016

This application note illustrates how pre-analytical deglycosylation of the antibody decreases data complexity and increases sensitivity that further improves upon the LB-MSIA work flow; a pre-clinical bio-analytical solution, based on mass spectrometric detection, specific for the bioanalysis of humanized and fully human therapeutic monoclonal antibodies using adalimumab in rodent plasma as a model biological system.

Finnpipette™ Novus Multichannel Pipettes

Thermo Fisher Scientific

Speed up repetitive dispensing into microplates. Thermo Scientific™ Finnpipette™ Novus Multichannel Pipettes feature a wide range of multichannel models for demanding laboratory tasks, including repetitive dispensing into microplates. The lightweight handle and module is designed with a balanced weight distribution preventing muscle stress and strain, and enabling longer work periods without fatigue. The light, long-lasting battery allows over 4000 pipetting actions. Features: Clear, easy to read, intuitive menu navigation New multilingual graphical user interface Backlight technology eliminates surrounding light reflections and improves contrast in low-light conditions Ten pipetting options; nine aspirate/dispense speeds Functions include forward, reverse, diluting, stepper pipetting, mixing, sequential stepping, and more Programmable for your own custom applications Easy in-lab calibration for accuracy and precision Fully autoclavable tip cone ensures sterility and avoids cross-contamination Long-life battery allows approximately 4000 pipetting operations; recharged in about one hour

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Finnpipette Digital - macro range

Thermo Fisher Scientific

Today’s laboratories require a sophisticated and reliable liquid handling approach that fulfills users’ needs and allows them to cope with the ever-increasing demands in daily work. Finnpipette Digital pipettes combine ergonomic design, advanced features and uncompromising performance to even better respond to various pipetting applications in modern laboratories. Product detail: Micro pipetting for small volumes - 0.2 to 1000 µl The use of expensive reagents has made micropipetting more necessary than ever, especially in the field of biotechnology. Working in the critical range of 0.2 to 1000 µl places tough demands on pipette performance. The Finnpipette Digital meets these demands, ensuring guaranteed accuracy and precision.  Macro pipetting for large volumes - 1 ml to 10 ml Thermo has applied the expertise gained in the years of pipette development to its macro range of digital Finnpipettes (1-5 ml and 2-10 ml). The results is a lightweight, easy-to-use pipette that avoids the risks associated with glass pipettes. All macro range Finnpipettes have a unique, specially designed piston assembly which completely eliminates vortex contamination, a common problem when pipetting large volumes. With it's up-to-date streamlined design, the Finnpipette Digital offers improved ergonomics for today's exacting laboratory routines. The rounded handle, modified grippy finger rest and the large display windows enhance operator comfort and efficiency. Finnpipette Digitals also feature several breakthroughs in liquid handling technology - soft-touch tip ejection with power-boosted gearing mechanism patented and super blow-out for 0.2 - 50 µl micro volume pipetting. For absolute sterility, all Finpipette Digitals are completely autoclavable. Each pipette also has a safety label on the finger rest, and they also come with a stick-on shelf hanger for convenient storage. 

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Thermo Scientific Versette

Thermo Fisher Scientific

The Thermo Scientific™ Versette is a compact automated liquid handler that offers 96- or 384-channel pipetting heads and user friendly programming options. Its reliable performance and compact size make it a flexible and convenient liquid handling solution for many kinds of laboratories. Versette is designed to perform a variety of liquid handling tasks for a wide range of applications including high-throughput immunoaffinity sample preparation with Mass Spectrometric Immunoassay (MSIA*) pipette tips. It also supports 96/384 plate replication, plate stamping and serial dilution procedures.Key Features: 96-and 384-channel pipetting heads Handle a total volume range of 0.5-300 µl All pipetting heads include RFID tags for self-identify, and utilize Thermo Scientific D.A.R.T.s tips Compact Size The six position stage uses a unique dual-level design to minimise space requirements Fits on standard benches and biological hoods User-friendly programming options: Simple pipetting procedures can be created using visual on-board graphical display For more complex protocols and advanced editing Thermo Scientific ControlMate software is available

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