Leveraging CRISPR-ready microglia for functional genomics studies
11 Jul 2024Microglia play a pivotal role in maintaining neural health, defending against pathogens, and maintaining the brain’s functional equilibrium. CRISPR-ready ioMicroglia from bit.bio have been engineered with precision reprogramming technology to constitutively express Cas9, enabling high knockout efficiency at protein level. Discover how CRISPR-ready ioMicroglia retains all the defining features of ioMicroglia, with no adverse effects on reprogramming potential, transcriptional profile, or functionality.
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ioMicroglia Human iPSC-derived microglia
bit.bioioMicroglia are human induced pluripotent stem cell (iPSC)-derived microglia, precision reprogrammed using opti-ox™ technology. Within 10 days post-revival, ioMicroglia are ready for experimentation, expressing (>90%) key markers, including TMEM119, P2RY12, and IBA1. ioMicroglia display key functional traits including phagocytosis and proinflammatory cytokine secretion and can be co-cultured with ioGlutamatergic Neurons™.