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Leveraging CRISPR-ready microglia for functional genomics studies

bit.bio
11 Jul 2024

Microglia play a pivotal role in maintaining neural health, defending against pathogens, and maintaining the brain’s functional equilibrium. CRISPR-ready ioMicroglia from bit.bio have been engineered with precision reprogramming technology to constitutively express Cas9, enabling high knockout efficiency at protein level. Discover how CRISPR-ready ioMicroglia retains all the defining features of ioMicroglia, with no adverse effects on reprogramming potential, transcriptional profile, or functionality.

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ioMicroglia Human iPSC-derived microglia

bit.bio

ioMicroglia are human induced pluripotent stem cell (iPSC)-derived microglia, precision reprogrammed using opti-ox™ technology. Within 10 days post-revival, ioMicroglia are ready for experimentation, expressing (>90%) key markers, including TMEM119, P2RY12, and IBA1. ioMicroglia display key functional traits including phagocytosis and proinflammatory cytokine secretion and can be co-cultured with ioGlutamatergic Neurons™.

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Flow Cytometry / Cell CountingFlow cytometers are used to count, sort and examine multiple characteristics of cells. Other cell analysis equipment includes image cytometers, cell counters, fluorescence-activated cell sorters (FACS), magnetic-activated cell sorters (MACS), and a range of flow cytometry assay kits. Flow cytometers can reveal information on cell viability, cell proliferation, apoptosis and cell cycle progression, as well as identify cell populations and intracellular or cell-surface molecules. Additionally, some flow cytometers, known as FACS, have an additional sorting function after analysis. Cell counters and image cytometers count live and dead cell populations and can also conduct cell proliferation assays. Find the best flow cytometers, cell counters and cell sorters in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.CRISPR/Cas9Target IdentificationRNA sequencingFunctional Genomics

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Leveraging CRISPR-ready microglia for functional genomics studies