ResourceClinical Diagnostics
Label-free Screening of Human Autoimmune Diseases
Label-free Screening of Human Autoimmune Diseases
10 Dec 2015Autoimmune diseases are caused by an immune response of the organism against its own cells and tissues as it does not recognize them as own constituent parts. One example for an autoimmune disease is the Hughes syndrome (antiphospholipid syndrome, APS). Hughes syndrome is derived from antibodies against cell-membrane phospholipid (aPL) resulting in thrombosis and complications during pregnancy like stillbirth, pre-term delivery, miscarriage or pre-eclampsia. This application note demonstrates the detection of specifically serological autoimmune antibodies using the Berthold Technologies bScreen with Biametrics 1lambda-RIDe technology.
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ImmunologyImmunological techniques measure and characterize immune responses. Immunology kits and analysis systems often use techniques such as ELISA, radioimmunoassay (RIA) and immunodiffusion assays, Immunohistochemistry, and flow cytometry. Immunologists use equipment such as flow Cytometers, plate readers, plate washers and fluorescent microscopes.Clinical ChemistryBiochemistry (or clinical chemistry) involves the analysis of bodily fluids using chemical tests. Techniques used include HPLC, chromatography, spectroscopy, mass spectrometry, immunochemical, electrophoresis, turbidometric / spectrophotometric assay, MRI and ISE analysis. Tests are often carried out on plasma or serum but urine (urinalysis) and fecal specimens are also processed.AutoimmunityAntibody ArraysMolecular DiagnosticsMolecular diagnostics use an individual’s genetic code and gene expression to diagnose and monitor diseases. The technique is used increasingly in the field of infectious diseases and oncology, as well as areas such as coagulation, HLA typing and pharmacogenomics. Molecular diagnostics plays a pivotal role in personalized medicine.Label-Free Analysis