KRAS Mutation Detection by Compact Sequencing Compared with Real-Time Detection PCR and Pyrosequencing in the Routine Clinical Laboratory
15 Nov 2013Patients with colorectal cancer and KRAS mutations do not benefit from treatment with monoclonal antibodies to epidermal growth factor receptor (EGFR). Therefore, KRAS mutation detection has been introduced into clinical practice. Several clinical laboratory methods have been established such as direct sequencing, pyrosequencing, and real-time detection PCR, which show varying detection limits and differing grades of automation.
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Anagnostics BioanalysisAnagnostics' hybcell is the world's first DNA or protein microarray based on the use of cylinders instead of slides. hybcell technology is... KINETIC - by means of consecutive scans, FAST - with help of rotational sample agitation, FLEXIBLE - due to fixed starting temperatures, flexible temperature profiles and computer-controlled buffer exchange and EFFICIENT - by automated processing and electronically documenting of up to 96 samples in a single run.