ResourceSpectroscopy

Intelligent flash purification using TLC and mass spectrometry

17 Feb 2023

The compound synthesis, purification and confirmation process often presents challenges throughout. From ensuring successful synthesis of your product, setting up a flash purification method, and finally confirming ID of fractions, the lengthy work flow can be time consuming and repetitive. In this application note, Advion demonstrates a new work flow that offers seamless steps to quickly and easily drive the process from reaction monitoring to flash purification and fraction ID.

Plate Express™ TLC Plate Reader

Advion Interchim Scientific

The Plate Express™ is a push-button TLC plate reader for results in <30 seconds. The system provides a simple, automated means of obtaining mass spectra directly from TLC plates, combined with Advion Interchim Scientific’s expression® compact mass spectrometer (CMS) creating a technique known as TLC/CMS.

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Intelligent flash purification using TLC and mass spectrometry