ResourceDrug discovery > Lead Discovery
Identifying a Diastereomeric Salt for a Challenging Chiral Resolution
17 Sept 2018Researchers at the Medicines for Malaria Venture were pursuing a promising candidate for the treatment of malaria when they ran into a roadblock. For over a year they attempted to develop a more direct method for isolating a key chiral intermediate. Until this challenge was overcome, the program was stalled and could not progress. Leveraging the power of Unchained Labs' Big Kahuna system configured for preformulation, they overcame this roadblock by identifying and scaling-up a viable chiral resolution method in just two weeks.
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High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.Compound AnalysisCompound analysis is used to discover specific compounds that could be promising candidates for pharmaceutical use. This potential is identified when compounds have the desired effect, such as interaction with a target protein, during high throughput screening.MalariaChiral CompoundsHigh ThroughputHigh throughput experiments allow the simultaneous processing of several samples. This parallelization reduces the cost per experiment and increases reproducibility and output volume of data.ScreeningUsing robotics, data processing and control software, liquid handling devices and sensitive detectors, screening allows a researcher to quickly conduct millions of chemical, genetic or pharmacological tests.Compound ScreeningCompound screening is a method used to discover specific compounds that could be promising candidates for pharmaceutical use. This potential is identified when compounds interact with the target protein during screening and could therefore be carried forward in the drug development process.