Why high-plex proteomics demands more from affinity reagents

7 Oct 2026

As proteomic assays scale to measure more proteins, the number of potential unintended interactions also increases, placing greater pressure on assay specificity, precision and reproducibility.

This infographic from Illumina examines how synthetic SOMAmer™ Reagents support specific protein measurement in high-plex assays. It introduces the combination of reagent properties and assay-design strategies used to challenge weaker, non-specific interactions while retaining intended protein-reagent complexes.

Explore why affinity-reagent specificity is fundamental to precise, scalable proteomic analysis.

Resource details

  • Resource type: Infographic
  • Page count: 2 pages
  • Read time: 4 mins

Illumina SomaScan Discovery Assay Services

SomaLogic

SomaScan™ Discovery services employ a highly multiplexed, sensitive, quantitative, and reproducible proteomic platform that profiles up to 11,000 human protein measurements in diverse sample types and species – without enrichment or depletion. Ideal for biomarker discovery, it supports basic, translational, pre-clinical, and clinical research across a wide range of diseases. SomaScan Discovery was previously known as the SomaScan 11K Assay. SomaLogic is an Illumina company.

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ProteomicsProteomics is the systemic bioinformatics study of proteins and amino acids, including their structure, size, function and identification. Tools used in proteomics include chromatography, blotting and gels, protein arrays, mass spectrometry and ELISA and associated analysis software. Analyzers and proteomic systems should be sensitive, high resolution, fast and may be automated for high-throughput.BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :Protein BiologyThe analysis of protein expression, identity and function is vital for many areas of life science research and drug discovery. Some of the most commonly used techniques in protein analysis include Western blotting, electrophoresis and mass spectrometry.