High Definition Multiple Reaction Monitoring: The Application of Quadrupole Ion Mobility Time-of-Flight Mass Spectrometry for Targeted Proteomic Studies
24 Jul 2013Recently the specificity of SRM/MRM peptide quantification has been questioned, prompting the use of high-resolution accurate mass instruments for peptide quantification. This application note demonstrates the benefits of the SYNAPT G2-Si System, in a new High Definition MRM mode, for the quantification of proteins and peptides.
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SYNAPT G2-Si HDMS
WatersThe Waters SYNAPT G2-Si High Definition Mass Spectrometry provides complete characterization of complex mixtures and molecules with unique levels of MS performance, industry leading informatics and unparalleled platform versatility.Through high-efficiency T-Wave™ ion mobility you can get superior separation, enhance the peak capacity, specificity and sensitivity of your analysis and transform your targeted and untargeted workflows. Ultimate UPLC/MS/MS performance, data independent and data dependant T-Wave IMS solution, CID and ETD fragmentation capabilities and a wide range of experimental options. This system gives you additional dimension of separation, based on molecular size and shape. It delivers a third dimension to your analysis, proven to transform your analytical perspective whatever the application.