HepatoPac™: A Bioengineered Micro-Liver Platform for Predictive Drug Metabolism and Toxicity Studies

Primary hepatocytes display a precipitous decline in phenotypic functions when cultured in a sandwich of extracellular matrix proteins (i.e. collagen, Matrigel). This severely limits the ability of these model systems to accurately predict clinical outcomes. This application note describes a human liver model with precise microscale cyto‐architecture and optimal stromal interactions (HepatoPac™) that displays high levels of liver‐specific functions for several weeks in vitro and has been shown to improve the predictions of clinical outcomes as compared to traditional approaches.