Evaluating AAV gene therapy vectors using differential scanning calorimetry

Gene therapy is a rapidly developing field with the potential to treat previously incurable diseases. Viral vectors, particularly adeno-associated viruses (AAVs), have become leading delivery platforms and account for a growing number of FDA-approved therapies. However, large-scale production of AAVs presents challenges, including contamination, ensuring vector integrity, and verifying proper gene encapsidation.

In this application note, TA Instruments highlights how nano differential scanning calorimetry (Nano DSC) can help address quality control and characterization challenges in AAV-based gene therapies.