ResourceLife Sciences
Evaluating AAV gene therapy vectors using differential scanning calorimetry
18 Feb 2026Gene therapy is a rapidly developing field with the potential to treat previously incurable diseases. Viral vectors, particularly adeno-associated viruses (AAVs), have become leading delivery platforms and account for a growing number of FDA-approved therapies. However, large-scale production of AAVs presents challenges, including contamination, ensuring vector integrity, and verifying proper gene encapsidation.
In this application note, TA Instruments highlights how nano differential scanning calorimetry (Nano DSC) can help address quality control and characterization challenges in AAV-based gene therapies.
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Thermal Analysis EquipmentThermal analysis equipment is used for measuring heat flow, weight loss, dimension changes or thermomechanical properties and is important for analyzing a material’s performance and stability. Thermal analysis equipment includes differential scanning calorimeters (DSC), thermogravimetric analyzers (TGA), thermomechanical analyzers (TMA), dilatometers, thermometers, vapor sorption analyzers, boiling and melting point apparatus. Thermal analyzers can reveal properties such as melting, crystallization and glass transitions or other processes such as oxidation, decomposition, volatilization, as well as coefficients of thermal expansion and modulus. Find the best thermal analysis equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.AVVGene TherapyGene therapy is a technique that modifies or replaces genes within an individual's cells to treat or prevent diseases. This approach holds potential for curing genetic disorders, cancers, and certain viral infections. Advances in gene editing technologies like CRISPR are driving the growth of gene therapy. Explore gene therapy tools and technologies in our peer-reviewed product directory; compare products, check reviews, and get pricing directly from manufacturers.