Enhancing research on bifunctional degraders
25 Nov 2024CETSA® (Cellular Thermal Shift Assay) is a method used in the study of interactions between small molecules and their protein targets. It is particularly useful in targeted protein degradation (TPD), providing valuable insights into degradation profiles. TPD represents a transformative approach in drug discovery yet is still only at the foundations of exploration. Discover how CETSA can elevate advances in monitoring molecular events to elucidate molecular dynamics and cellular effects to benefit pharmaceutical solutions.
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Target Deconvolution with CETSA
Pelago BioscienceTarget Deconvolution service based on proteome-wide Cellular Thermal Shift Assay using Mass Spectrometry detection is performed in intact cells and lysate without any compound modifications.
Primary Screening with CETSA
Pelago BiosciencePrimary screening based on Cellular Thermal Shift Assay (CETSA) allows for rapid identification of high quality chemical starting points against the native, full-length protein in live cells.
Hit confirmation with CETSA
Pelago BioscienceHit confirmation service is based on the Cellular Thermal Shift Assay (CETSA) and allows for assessment of compound binding to a selected target protein in its native state without any modifications to the protein or the compound.