Enhanced renal toxicity screening by integrating Incucyte® & EpiKidney™

Drug- and chemical-induced nephrotoxicity is a major cause of drug failure and withdrawal. Traditional kidney toxicity tests and animal models often miss human-specific renal injury, leading to costly late-stage surprises. Mattek’s EpiKidney™ is a 3D human in vitro kidney model engineered for sensitive, human-relevant nephrotoxicity testing and renal safety assessment. By closely mimicking human kidney physiology, EpiKidney™ improves prediction of drug-induced kidney injury. This kidney toxicity platform integrates with the Incucyte® Live-Cell Analysis System for high-content, real-time imaging, enabling:

• Rapid dose-range finding
• Early detection of renal injury biomarkers
• Quantitative kidney toxicity profiling of drug candidates

EpiKidney™ streamlines toxicity quantification, strengthens preclinical safety decisions, and helps reduce nephrotoxicity-related clinical failures and market withdrawals.