ResourceLife Sciences
Dual-specific SOMAmer reagent identifies key biomarker for aging diseases
8 Sept 2026This case study highlights how a dual-specific SOMAmer™ Reagent was used to identify activated GDF11/8 as a predictive biomarker for cardiovascular disease, mortality and dementia risk. Discover how researchers resolved discrepancies between mass spectrometry and aptamer-based measurements by detecting a clinically relevant activated proteoform not captured by conventional approaches. Explore how activated GDF11/8 demonstrated strong predictive value across multiple independent cohorts and how Single SOMAmer Reagents can reveal novel biological insights and therapeutic opportunities in aging research.
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Resource type: Case study
Page count: 2
Read time: 4 mins
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BiomarkersBiomarkers are biological markers which can be measured and evaluated to indicate a biological state. The use of biomarkers in research and diagnosis can indicate a normal or disease state or drug response of cells / tissues. Biomarkers include genetic markers, cell surface markers such as antigens, antibodies or receptors and secreted molecules such as cytokines. An assay system is required for identification of biomarkers. :