Development of a platform SEC-MALS method for therapeutic monoclonal antibodies

In biotherapeutics manufacturing, controlling the size distribution of therapeutic monoclonal antibodies (mAbs) is critical to ensuring product quality. Size-exclusion chromatography coupled to multi-angle light scattering (SEC-MALS) is a leading method for analyzing size variants by separating high and low molecular weight species from the monomer based on their hydrodynamic volume.

Learn how the analytical team at Tanvex BioPharma, Inc. found SEC-MALS to be an advantageous method which is cost-effective and efficient for analyzing size variants across a broad range of mAbs.