Detecting the Presence of Anomolous Large Particles within Powders Using Laser Diffraction Particle Size Analysis

This application note demonstrates the ability of the Mastersizer 3000 and Aero S dispersion unit to detect a small proportion of anomalously large particles added to a small aliquot in a 'seeding' experiment. A fine grade of lactose was used as a model for pharmaceutical API or excipient powders.