Decoding disease epigenetics: Innovating DNA methylation with advanced sequencing methods

Explore how the Functional Epigenetics Laboratory at KU Leuven in Belgium has integrated the Agilent Fragment Analyzer system into its workflow to maximize efficiency, especially during single-cell nucleosome, methylome, and transcriptome sequencing (scNMT-seq). This technique allows for the simultaneous analysis of chromatin accessibility, DNA methylation, and gene expression within individual cells.

Discover how the lab also uses the Agilent HS NGS Fragment kits with the Fragment Analyzer due to the high-sensitivity analysis, which is crucial for NGS library QC from limited DNA amounts. The libraries often contain minimal DNA after the scNMT-seq protocol, making these kits essential.