Choosing the right ITC binding experiment

23 Jan 2026

This resource by TA instruments covers how Isothermal titration calorimetry (ITC) enables researchers to gain a complete understanding of the thermodynamic driving forces behind binding interactions. Explore three ITC methods and learn how each approach offers unique benefits depending on the stage of the workflow. Discover how enthalpy screening and continuous titration can streamline experiments and reduce overall experimental time.

Resource details:

  • Document type: Application notes
  • Page count: 2
  • Read time: 3 mins

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TitrationTitration is an analytical technique for determining substance concentration in a solution. For titration consider a manual or automated system, volumetric or coulometric reagent addition and indication by a potentiometer, spectrometer, turbidometer or by the Karl Fischer method. Other features of titration to consider include burettes, reagents, concentration range, reaction time and autosamplers.High-Throughput ScreeningHigh-throughput screening (HTS) is an automated drug discovery technique for identification of active compounds against a compound library. Use HTS readers and integrated assay preparation / analysis workstations to screen your compounds. Identify active compounds against various HTS libraries, including membranes, proteins and peptides and HTS cell lines. Find the best high-throughput screening products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.isothermal titration calorimetry
Choosing the right ITC binding experiment guide - SelectScience resources