Charge Heterogeneity Analysis of Rituximab Innovator and Biosimilar Monoclonal Antibodies
25 Jan 2018Recombinant monoclonal antibodies (mAbs) are important biotherapeutics with a wide range of diagnostic and clinical applications. Recently, biosimilar products are increasing in popularity in biopharmaceuticals. This study performs high-resolution separation of charge variants of innovator and biosimilar rituximab using an Agilent 1260 Infinity Bio-inert Quaternary LC, biocolumns, and an Agilent OpenLAB ChemStation Software tool.
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Agilent 1260 Infinity II Bio-Inert LC System
Agilent TechnologiesThe 1260 Infinity II Bio-Inert LC is a dedicated solution for analysis of large biomolecules in biological samples, including monoclonal antibody (mAb) and protein analysis. Metal-free components in the sample flow path and the absence of iron and steel in solvent delivery lines ensure the integrity of your biomolecules, minimize unwanted surface interactions, and increase column lifetime.
OpenLAB CDS ChemStation Edition
Agilent TechnologiesOffers the most complete instrument control of Agilent LC, GC, CE, CE/MS, and LC/MS instruments systems you have now, with limited instrument control of other vendors’ systems. Plus, take full advantage of the advanced features of the Agilent GC and LC instruments you have now and new instruments, when released.