ATR Imaging of Pharmaceutical Tablets
2 May 2011In this application note by PerkinElmer, ATR imaging measurements of commercial pharmaceutical tablets are developed. This technique shows a major advance in state of the art pharmaceutical tablet imaging. It provides an improvement in achievable spatial resolution compared with NIR chemical imaging, and sharper, generally easier to interpret images. The technique overcomes the major limitation of direct diffuse reflectance imaging in the mid-IR, namely problems with high signal attenuation and uncontrolled specular reflectance contributions in the image. It also avoids some of the limitations of Raman imaging such as sample overheating, potential fluorescence, limited spatial resolution (depending on Raman hardware configuration) and relatively long image collection times.
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Spotlight 400 FTIR Imaging System
PerkinElmerThe Spotlight 400 FTIR Imaging System combines high sensitivity and rapid imaging with ease-of-use. The ability to image rapidly large sample areas at high spacial resolution (down to 10 microns) extends IR microscopy into new application areas such as the study of biomaterials such as tissue, bone, leaves etc. The Spotlight 400 can be used in the mid- or near-IR spectral ranges, as well as dual-range, depending on whether, respectively, the Spectrum 100, Spectrum 100N or Spectrum 400 mid-/near- spectrometer is used.Spotlight 400 FTIR Imaging System Features: Solid-state white light illumination. Fully-automated focus, stage movement and illumination. Duet™ detector design containing a single element MCT detector and a linear array MCT imaging detector. Very high sensitivity providing high quality data down to the accepted diffraction limits Rapid-scan IR imaging. 6.25µm, 25µm and 50µm pixel resolution to give flexibility in spacial resolution and imaging line. Can operate in mid-IR, near-IR or dual range to cover the full range of imaging applications in one instrument. Optional ATR imaging improves the spacial resolution by a factor of four, down to 3 microns at 1000 cm-1