ResourceSpectroscopy

Analysis of pharmaceutical raw materials using the tri-range Spectrum 3 FT-IR Spectrometer

27 Mar 2023

Infrared Spectroscopy has become a ubiquitous tool in the analysis of pharmaceutical raw materials, with both mid- and near-infrared spectroscopy functioning as commonplace techniques for the investigation of both excipients and active pharmaceutical ingredients (APIs). Near-infrared spectroscopy is arguably the most common spectroscopic technique for the interrogation of incoming raw materials. Mid-infrared spectroscopy generally contains the most information regarding the chemical structure of an analyte, making it particularly useful for identification and analysis of active materials in pharmaceutical samples.

This application note describes how the PerkinElmer Spectrum 3™ FT-IR spectrometer together with the 21 CFR part 11 compliant Spectrum 10 software provides a high-performance solution for mid and near infrared analysis of materials used in the pharmaceutical industry.

Spectrum 3 FT-IR Spectrometer

PerkinElmer

From routine identification and verification to advanced research applications, you need the performance and flexibility to quickly, confidently, and cost effectively analyze a wide range of samples. The PerkinElmer Spectrum™ 3 FT-IR spectrometer provides the sampling flexibility and performance in mid, near, and far infrared ranges through a single instrument to advance research and new product development in academia, chemicals, polymers, and pharmaceuticals. The highly configurable platform provides dependable, consistent, and trouble-free operation through years of service. Spectrum 3 is loaded with a range of advanced innovations designed to provide you with exceptional performance and flexibility from the configuration you choose. Performance: Exceptional signal-to-noise ratio and photometric performance High reproducibility of spectral data without spectral interferences Best-in-class sensitivity, even when using room temperature detectors Characterize fast reactions with scan speed up to 100 scans/sec Optimize sensitivity and spectral resolution performance Flexibility: Maximize instrument uptime with a wide range of quickly interchangeable accessories Simplified TG-IR hyphenation experience from a single vendor Collaborate from any device, anywhere, any time with cloud connectivity Perform routine analyses faster with on-instrument SmartPanel Upgradeable to IR microscopy and imaging

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