ResourceSpectroscopy
Analysis and characterization of GLP-1 receptor agonists
9 Jul 2026This resource by Waters presents a comprehensive analytical workflow for the analysis and characterization of GLP-1 receptor agonists (GLP-1 RAs), including therapies such as semaglutide, liraglutide, exenatide, dulaglutide, and tirzepatide. It focuses on critical quality attributes (CQAs) including identity, purity, stability, and safety. It also demonstrates how reversed-phase liquid chromatography–mass spectrometry (RPLC-MS), amino acid analysis, peptide mapping, and size-exclusion chromatography with multi-angle light scattering (SEC-MALS) can be used to detect impurities, confirm peptide identity, monitor degradation, and characterize oligomers and aggregates.
Resource details:
- Resource type: Application note
- Page count: 15
- Read time: 26 mins
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LC-MSLC-MS (liquid chromatography-mass spectrometry) systems and equipment are used for separation and quantitative analysis of complex mixtures, combining liquid chromatography and mass spectrometry. Quantify proteins, contaminants, pesticides or screen for drug metabolites with a high level of sensitivity. LC-MS systems and equipment include reverse phase, normal phase and specialized columns integrated with various MS detectors such as time-of-flight (TOF), quadrupole, orbitrap or ion trap mass analyzers. LC-MS/MS instruments equipped with a qTOF or triple quadrupole analyzer give greater sensitivity and resolving power to your analysis. Find the best LC-MS equipment in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.BiopharmaceuticalsBiopharmaceuticals are proteins and other compounds (such as nucleic acids) produced by living organisms that have uses as therapeutics or for in vivo diagnostics. The most well known example of a biopharmaceutical product, and the first to be approved for therapeutic use, was recombinant human insulin.Peptide MappingAmino Acids
