ResourceClinical Diagnostics
Accurate, IVDR compliant NGS variant calling using the Illumina DRAGEN Server for NextSeq 550Dx Instruments
19 Mar 2026In this application note, Illumina highlights how the DRAGEN™ Server for NextSeq™ 550Dx enables fast and highly accurate variant calling for diagnostic next-generation sequencing workflows. Illumina describes a complete DNA-to-data solution combining Illumina DNA Prep with Enrichment Dx library preparation, sequencing on the NextSeq 550Dx Instrument, and secondary analysis with DRAGEN software, and demonstrates how this workflow supports flexible, easy-to-use targeted enrichment for in vitro diagnostic applications.
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NextSeq™ 550Dx Instrument
IlluminaBenchtop IVD sequencing to enable labs to run diagnostic assays and develop a range of applications from targeted panels to WGS
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Next Generation SequencingNext-generation sequencing (NGS), also known as whole-genome sequencing, high-throughput sequencing and massive parallel sequencing, produces and analyses thousands to millions of nucleotide sequences at once. Sequencing systems operate via varying technologies depending on the manufacturer, including sequencing by synthesis, ligation, pyrosequencing, ion semiconductor and single-molecule real-time sequencing. For NGS, library preparation is paramount to successful sequencing. In this section, explore a range of library preparation kits, from targeted, amplicon-based or hybridization-based kits including epigenomic, transcriptomic and genomic workflows to fragmentation kits. Find the best next-generation sequencing products in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.