LC-MS Services Products & Reviews

Our Metabolite Identification service employs HRMS /LC-MS/MS to decode degradation pathways of antisense oligonucleotides (ASOs), siRNAs, and modified variants, identifying chain-shortened metabolites (5’/3’ cleavage), phosphorothioate changes (desulfurization, inversion) and base/nucleotide alterations (deamination/depurination). Through plasma/tissue/cell analysis, we reveal metabolic stability, biodistribution, and exonucle…

Alfa Chemistry’s Deformulation and Reverse Engineering Services provide analysis of product composition, material structure, and formulation using qualitative and quantitative techniques. The service supports ingredient identification, formulation profiling, and structural analysis to aid product improvement, quality benchmarking, supply continuity, and technical comparison across diverse materials.

Alfa Chemistry’s Pharmaceutical Analytical Services offer expert testing and characterization throughout drug development and production. Using a cGMP-compliant laboratory and advanced analytical techniques, we provide biopharmaceutical characterization, impurity profiling, stability assessment, and formulation analysis to ensure product safety, efficacy, and regulatory compliance.

Our industry leading  bioanalytical solutions have helped our clients develop  new peptide therapeutics  to improve the quality of life. Combining our experience and cutting-edge technology, we have has developed and validated methods using LC-MS/MS to quantify levels of peptides in plasma at levels as low as 10 pg/mL.