Drug Delivery > Dissolution Apparatus Products & Reviews

An automated dissolution testing system using UV-Vis analysis     The Agilent Multicell UV Dissolution System is one of the most innovative and flexible tablet dissolution systems on the market. The system provides a fully integrated, automated dissolution testing system using the award-winning Cary 50 UV-Vis spectrophotometer, ensuring a highly efficient and rugged solution to online dissolution/UV-Vis analysis.

Cary WinUV dissolution software supports both Agilent multicell and fiber optic online UV dissolution systems. The software generates accurate and reliable data and accommodates a wide variety of dissolution samples and methods. Analysts can easily customize final reports with a complete summary of the data acquisition using comparison and statistical evaluation tools, data tables and dissolution profiles.

The Cary 8454 UV Dissolution System is an ideal solution for single and select multicomponent product analysis using diode array technology. Multicell- or valve-based systems, as well as a multi-apparatus system, are available and provide specific benefits depending on the end user environment.

The Distek Model 2500 Dissolution System offers great flexibility and configurability. It can be configured as USP Apparatus 1, 2, 5, and 6 plus intrinsic dissolution. The extensive users, method, and reporting storage capabilities are enabled by a brilliant touch screen.   

Greater data quality and enhanced analysis   Using the Cary 50 Spectrophotometer with powerful Xenon pulse lamp and in situ fiber-optic probes, you can instantaneously scan and read dissolution measurements. The Agilent Fiber-Optic UV Dissolution System offers versatility and flexibility while delivering the highest level of automation and data integration for all of your UV dissolution needs. The system uses the award-winnin…

No more sampling! The Distek Opt-Diss 410 in-situ fiber optic UV system measures directly in the vessel, eliminating the need for conventional sampling, and with-it consumables like filters, tubing, and syringes, saving time, labor, and money. Moving light rather than liquids also allows generating near real-time dissolution data and nearly limitless sample points as frequently as every five seconds.  

The flexible Freedom EVO platform offers numerous options for automated sample preparation processes, and can be tailored to specific laboratory needs.

The fully programmable Agilent 100 automated disintegration apparatus provides a reliable, compliant approach to disintegration testing. The reciprocating drive system, water bath, and heater/circulator are incorporated into a single instrument with a compact, bench space-saving design. 

Agilent dissolution workstation software integrates dissolution apparatus and automated sampling components to simultaneously control up to four systems of any configuration from a desktop PC.

The Agilent 280-DS mechanical qualification system (MQS) enables the physical qualification of any dissolution apparatus per enhanced Mechanical Qualification (eMQ) guidelines. Once positioned, the innovative sensing technology allows hands-free measurements to be performed in seconds while measuring and recording critical physical parameters.

Using the same platform as the 708-DS, the 709-DS Dissolution Apparatus ensures productivity, reproducibility and ease of use combined with the convenience of a bath-free design. The 709-DS reduces media heating time with Direct Vessel Heating (DVH) capabilities while insulating the vessel from environmental factors and eliminating water bath cleaning. The exclusive design of the chemically resistant, DVH TruAlign vessel incor…

The 850-DS Dissolution Sampling Station offers the latest capabilities for centralizing laboratory workflow of sample transfer, filtration and collection.

The 708-DS dissolution apparatus is a modular system designed for manual or automated dissolution testing. The instrument can be configured for use with baskets (Apparatus 1), paddles (Apparatus 2), paddle over disk assemblies (Apparatus 5), and rotating cylinders (Apparatus 6), and can accommodate vessel sizes from 100 mL to 2 L.

The Agilent BIO-DIS reciprocating cylinder apparatus (Apparatus 3) is designed to meet current USP Apparatus 3 and EP Reciprocating Cylinder specifications. It is typically used for testing dosage forms in an environment where the the pH/gastrointestinal changes that occur in the body are simulated.

The Agilent reciprocating holder apparatus (USP Apparatus 7) is ideal for automatic dissolution testing of dosage forms requiring a change of media, smaller volume or more vigorous agitation. Typical products tested include extended release tablets, capsules, transdermals, osmotic pumps, and arterial stents.  

The Agilent 400-DS apparatus 7 enables simultaneous, small-volume drug-release testing of up to 13 samples. The 400-DS is designed for testing novel dosage forms such as combination drug products. The innovative design incorporates both the dissolution apparatus and the autosampler.

The NanoDis System provides formulation scientists with accurate release profiles of APIs using conventional dissolution apparatus in an automated, compliant manner. This functionality enables analysts to uncover the best nanoparticle formulation faster and get new drug formulations to market more quickly.  

The intrinsic dissolution apparatus provides the dissolution rate of a pure active pharmaceutical ingredient (API) by exposing the API to a constant surface area of dissolution medium.

The Enhancer (immersion) Cell is a PTFE cell with adjustable volume and a retaining cap to eliminate air pockets trapped against the skin or artificial membrane that provide the diffusion barrier.

Innovative diamond-like carbon (DLC) coating technology overcomes the problems associated with PTFE and improves robustness.    

Alfa Chemistry’s Pharmaceutical Analytical Services offer expert testing and characterization throughout drug development and production. Using a cGMP-compliant laboratory and advanced analytical techniques, we provide biopharmaceutical characterization, impurity profiling, stability assessment, and formulation analysis to ensure product safety, efficacy, and regulatory compliance.

The Distek Model 2500 RTD Dissolution System offers great flexibility and configurability. It can be configured as USP Apparatus 1, 2, 5 and 6 plus intrinsic dissolution. The extensive users, method and reporting storage capabilities are enabled by a brilliant touch screen. Patented wireless temperature sensors continuously monitor and display the in-vessel temperature for each vessel.   

The Distek Model 2500 Select Bathless Dissolution System is the culmination of three generations of patented bathless technology with extremely short media heating times and dramatically smaller energy use. Unparalleled control of the instrument plus automatic storage of component serial numbers and automatic qualification reminders makes the Model 2500 Select robust and reliable enough for QC applications yet flexible enough…

Performing dissolution tests on high potency drugs with low concentrations of active pharmaceutical ingredients is difficult, if not impossible, with a standard apparatus 1 or 2 dissolution bath. Common analytical instruments are not sensitive enough to detect such low concentrations. Distek's Small Volume Conversion Kit offers the perfect solution to these common dilemmas.  

The Distek Eclipse 5300 Automated Dissolution Sampler offers rapid, accurate sampling using precision syringe pumps. The elimination of valves and rotary pumps along with the optimized sample pathway increases reliability while reducing common sources of sample carryover.