High-Content Screening Products & Reviews

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High-content screening (HCS), also known as high-content analysis (HCA), is a high-throughput technique used in drug discovery to identify substances that alter the phenotype of cells. HCS uses fluorescent microscopic imaging and automated image analysis to investigate cellular events such as apoptosis, cell viability, GPCR activation, oxide production, neurite outgrowth, and cell signaling. Find the best fluorescent labeling reagents, cellular assays, and high-content imaging systems in our peer-reviewed product directory: compare products, check customer reviews and receive pricing direct from manufacturers.

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XcytoMatic® High-throughput cell density analyzer

ChemoMetec

The XcytoMatic® 40 (XM40™) is a high-throughput cell density and viability analyzer that can run 24 samples in under 14 minutes. The variation between cell counts for these samples is under 3%. If scale-out and scale-up is a concern, you can trust each XM40™ instrument in your production to deliver the same quality results.

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Single Cellome™ System SS2000

Yokogawa Corp. of America

The Single Cellome™ System SS2000 is a dual microlens spinning disk confocal system for live-cell high-content imaging which can sample adherent single cells. Combining imaging with sampling ensures the preservation of spatial, morphological, and temporal information of samples for flexible downstream mass spectrometry and sequencing applications.

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CellVoyager CQ3000

Yokogawa Corp. of America

High-content live cell microscope with dual camera, dual microlens spinning disk confocal. Water immersion lenses for superior image quality and uniformizer for consistent illumination and widefield capability. A total imaging solution suitable for any sample, from fixed to live and from 2D cultures to 3D organoids; scalable for any applications, from basic research to large-scale screening.

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CellVoyager CV8000

Yokogawa Corp. of America

Flagship high-content live cell screening system equipped with dual microlens spinning disk confocal and up to 4 cameras maximizes throughput without sacrificing image quality. Kinetic liquid handling and built-in incubator enables studies of fast events in living cells. Flexible imaging modalities, acquisition configuration and analysis routines let you image in all dimensions.

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In Vitro Angiogenesis Assay Kit

Merck

The CHEMICON In Vitro Angiogenesis Assay Kit provides a convenient system for evaluation of tube formation by endothelial cells in a convenient 96-well format. When cultured on ECMatrix™, a solid gel of basement proteins prepared from the Engelbreth Holm-Swarm (EHS) mouse tumor, these endothelial cells rapidly align and form hollow tube-like structures. Tube formation is a multi-step process involving cell adhesion, migration,…

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Fibrin In Vitro Angiogenesis Assay

Merck

The CHEMICON Fibrin Gel In Vitro Angiogenesis Assay Kit provides a convenient system for evaluation of tube formation by endothelial cells in 96-well or other formats. When cultured on top or within a fibrin gel, endothelial cells rapidly align and form interconnecting networks that can display patent lumina2,3. Tube formation is a multi-step process involving cell adhesion, migration, differentiation and growth4. The formatio…

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In Vitro Vascular Permeability Assay

Merck

The CHEMICON® In Vitro Vascular Permeability Assay is performed in a 24-well tissue culture plate with 12 cell culture inserts. The inserts contain 1.0 μm symmetrical pores within a transparent polyethylene membrane. The high pore density membranes permit amplified rates of basolateral diffusion with molecules of interest for permeability assays. The membrane is tissue culture treated on both sides for cell growth. Within CHE…

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Millicell μ-Migration Assay Kit

Merck

Live cell tracking of single cell or cell population migrationEstablishes a stable and linear concentration gradient that lasts ≥ 48 hoursHelps distinguish chemotaxis from random movementAllows for multiparametric analysis, including cell directionality and velocityEnhanced optical imaging of slow- and fast-migrating cellsAnalyze 3 chemoattractants in parallel for increased throughput and flexibilityNo need to spend time or mo…

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Millicell® μ-Angiogenesis Activation and Inhibition Assay Kits

Merck

The Millicell μ-Angiogenesis activation and inhibition kits provide a powerful, quantitative platform for real-time monitoring of changes in tubule formation with unprecedented optical resolution.Continuous, live monitoring of cells as tubules formEven, flat slide surface prevents any liquid meniscus from forming, eliminating out-of-focus areasFull well visualization at low magnificationOptimized assay conditions in a miniatur…

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Cell Health Profiling V2 Image Analysis BioApplication for Apoptosis and Cytotoxicity

Cell Health Profiling V2 is a flexible image analysis application employing advanced cell-level logic to detect and classify cell health-related events.  It analyzes patterns of cellular fluorescent labeling that can be used to classify cells as undergoing apoptotic, necrotic, or other cell death mechanisms.  This application has been biologically validated, enhancing confidence in your image-based data.  Available for the Cel…

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Cell Cycle V2 Image Analysis BioApplication

The Cell Cycle V2 BioApplication is a sophisticated image analysis algorithm that performs automated analysis of the cell cycle phase of individual and populations of cells.  It reports cell cycle phase as well as the state of up to 3 target proteins for every cell analyzed, and correlates the target data with DNA content.  This application has been biologically validated, enhancing confidence in your image-based data.  Availa…

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Cytek® Northern Lights

Cytek Biosciences

The Cytek team has reimagined what is possible from an affordable, 3-laser flow cytometer. The Cytek ® Northern Lights incorporates the same groundbreaking full spectrum technologies as the Cytek ® Aurora. This means that with just the blue laser, you can run 9-color panels. And with upgradability to 3 lasers and 25+ color panels, the Cytek ® Northern Lights allows researchers to truly maximize the value from each laser.

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