Process chemistry is an important stage of drug development for scaling-up drug production or chemical synthesis reactions. It is useful for optimizing economical and efficient drug production. Process chemistry uses reactors and pump systems as well as reagents, standards and buffers.
Efficiently design, synthesize, characterize and screen libraries of catalyst materials by combining custom hardware and software capabilities. Create and test hundreds of heterogeneous catalyst materials per week using a variety of fully automated techniques. The automated nature of the workflows increase reproducibility and provide a complete experimental record. Prepare: Synthesize diverse arrays of heterogeneous catalyst…
Consistently design, synthesize, screen, and analyze reactions using this automated, high throughput workflow. Significantly increase the number of high quality experiments per year while decreasing experimentation time and manufacturing costs. The Homogeneous Catalysis Workflow utilizes a high pressure reactor (HPR), parallel batch reactor (PBR), and a parallel pressure reactor (PPR) to screen hundreds of reactions per day un…
Perform 48–96 meaningful slurry or solution phase (co)polymerizations per day and increase the productive value of research and development by enabling better decisions, faster. Through the integration of reactor hardware, robotics, and custom software capabilities, the Polyolefins Workflow facilitates 48–96 slurry or solution-phase batch reactor polymerizations with full computer control and in situ temperature and pressure m…
Start-to-finish solution for solubility profiling. The Solubility Workflow enables precise and accurate measurement of the solubility of compounds starting from solid forms or solutions of active pharmaceuticals and intermediates. It is also available in a Benchtop Systems configuration. The Benchtop System is a self-contained, software-driven system, while the integrated workflow connects with other equipment in the lab and s…
Efficiently design, automate and implement consistent forced degradation studies. Quickly identify degradation conditions and potential degradants by automating the testing of solid and solution state samples, while visualizing and recording key variables of degradation experiments. By combining hardware and software capabilities, the Forced Degradation Workflow builds consistent libraries to facilitate data analysis and drive…
Efficiently design, automate, and implement consistent excipient compatibility studies. Quickly identify conditions, potentially incompatible excipients or excipient combinations by automating the testing of solid and solution state samples, while visualizing and recording key variables of excipient experiments. By combining hardware and software capabilities, the Excipient Compatibility Workflow builds consistent libraries to…
Consistently design, synthesize, screen, and analyze reactions using this automated, high-throughput workflow. Significantly increase the number of high quality experiments per year while decreasing experimentation time and manufacturing costs. The Organic Synthesis Workflow utilizes a parallel batch reactor (PBR) to screen hundreds of reactions per day under different stoichiometries, reaction concentrations, and temperature…
Design, implement, and characterize formulations using the automated Adhesives, Coatings and Sealants Workflow Rapidly and precisely formulate libraries, measure and adjust viscosity, prepare thin coatings on various substrates, and measure their properties. The Adhesives, Coatings and Sealants Workflow utilizes multiple Core Modules equipped with liquid handling, heating/stirring, viscometric indexing, and a drawdown tool to…
Offered in a number of customized configurations, the Symyx Home and Personal Care workflow allows you to formulate, apply, and test materials more quickly than ever before. By combining Symyx hardware and software capabilities, this workflow enables you to develop and optimize new formulations, apply formulations to various substrates, and rigorously evaluate these applications using a wide variety of testing conditions. Pre…
Perform 48–96 meaningful slurry or solution phase (co)polymerizations per day and increase the productive value of research and development by enabling better decisions, faster. Through the integration of reactor hardware, robotics, and custom software capabilities, the Plastics Workflow facilitates 48–96 slurry or solution-phase batch reactor polymerizations with full computer control and in situ temperature and pressure moni…
An automated platform for parallel synthesis and polymerization studies over a range of controlled temperatures and pressures in the chemicals and pharmaceuticals laboratoryThe modular PPR, with hardware and software capabilities, provides a fully automated robotic platform in which up to 48 isolated reactions can be conducted in parallel. The system enables a scientist to design experiments, execute syntheses, monitor convers…
Create formulations for stability and compatibility tests. Generate and test hundreds of complex liquid formulations at a time using the automated Liquid Formulations Workflow. Use visual, chromatographic, or spectroscopic tools to monitor the stability of the libraries of samples. It is also available in a Benchtop Systems configuration. The Benchtop System is a self-contained, software-driven system, while the integrated wor…
FRX200 is a flexible system enabling solid phase or solution phase chemistry on mg - kg scale and multi step chemistry. FRX200 is designed to give a wide range of options for people wanting to investigate flow chemistry. Allowing users to conduct solid-phase chemistry in addition to multi-stage synthesis and reactions under pressure. FRX200 combines a range of reactors (micro rectors, tube reactors and solid-phase columns) w…
FRX300 is a complete workstation giving any chemist a wide range of experimental possibilities with flow reactions. By including the FLLEX, liquid-liquid extraction module, FRX300 allows materials to be prepared and worked up automatically. FRX300 provides an introduction to automatic workup of flow reactions. With integrated injection loops to add materials to the flow and a range of different volume reactors, FRX300 gives us…
The FRX400 includes all the functionality of FRX300 but also has the full range of Syrris reactors, 4 Pumps, 2 Hotplates, 2 Reagent Modules and the Cooling Insert. This enables up to 4 inputs into a multi step reaction or 3 inputs and an immiscible aqueous work-up stream, reaction steps at different temperatures, cooling to -20°C and injection of small quantities of up to 4 reagents via sample loops. The FLLEX (Flow Liquid Liq…
The Atlas Syringe Pump is a versatile volumetric dosing system that consists of two syringes and can be configured into 2 refilling flows or 1 continuous flow. It can operate in isolation by use of the intuitive twist and click knob and display or can be controlled by the Atlas Base. A choice of dosing modes allows simple additions or intelligent active control of parameters including pH and temperature.
The Orbit from Syrris is a high performance, low cost parallel synthesis module for research and development chemistry. It fits conveniently on an Atlas hot plate, Atlas hot/cold plate or regular hotplate. 6 or 12 reaction tubes can be magnetically stirred in an inert atmosphere and be heated to 280°C with reflux or cooled to -40°C.
The Remote Mount allows a vessel assembly to be located away from the Atlas Base. The Remote Mount can attach to standard lab scaffolding and is connected to the Atlas base using an umbilical. When the Jacketed Vessel Clamp is used with the Remote Mount, it is compatible with vessels of up to 5 litres.
The Atlas Hot and Cold Plate is an easy and accurate way of heating and cooling reactions in flasks or vials. Designed to fit on the Atlas Base, the Hot and Cold Plate connects to a recirculating heater/cooler to provide temperature control from -40°C to +160°C. When a controllable circulator is connected to the Atlas Base, the Hot and Cold Plate or reaction can be accurately controlled to the temperature set on the Atlas Base…
Atlas Lithium automates reactions in round bottomed flasks or vials. The Hotplate and Stacking Dry Bath can heat round bottom flasks from 50ml to 1 litre (to 280°C) giving excellent thermal transfer to the reaction yet the exterior surface remains cool to the touch. The Atlas Clamp holds a range of different vessel sizes securely and automatically aligns flasks to the dry bath.
The Atlas Syringe Pump is a versatile volumetric dosing system that consists of two syringes and can be configured into 2 refilling flows or 1 continuous flow. It can operate in isolation by use of the intuitive twist and click knob and display or can be controlled by the Atlas Base. A choice of dosing modes allows simple additions or intelligent active control of parameters including pH and temperature.
Based on an Atlas Potassium, the Atlas Gravimetric Dosing system allows a defined mass of reagent to be pumped from a balance to the reactor by a controlled peristaltic pump. The mass flow rate can be defined, monitored and adjusted by using the Atlas Software.
Based on an Atlas Potassium, the Atlas Reaction Monitoring system includes additional temperature nodes and RTD probes to monitor the jacket temperature. The Reaction Monitoring system can use a combination of reaction temperature and jacket temperature to accurately monitor both exothermic and endothermic reaction processes either using the Atlas software or through the Atlas base.
AutoPlant / MultiPlant: Solutions for Process R&D, Polymer Synthesis and Preparative Synthesis The Chemspeed MultiPlant and AutoPlant workstations offer targeted solutions for Process R&D, Polymer Synthesis and Preparative Synthesis. The leading edge MiniPlant technology allows scientists to truly mimic the final industrial production process and provides all the required flexibility to optimize integrated reaction sequences,…
Waters offers PoraPak™ Rxn, a family of polymer-based chromatography products for superior cleanup of synthetic reactions. PoraPak Rxn products are available in two chemistries: PoraPak Rxn CX, a strong cation-exchange sorbent and PoraPak Rxn RP, a reversed-phase sorbent.PoraPak Rxn sorbents are based on copolymers that exhibit the following properties:Hard material that does not develop increasing back pressure with flowLitt…
