Next-Generation Sequencing Products & Reviews

The Twist 96-Plex Library Preparation kit enables high-throughput library construction for whole genome sequencing. 

The Twist Alliance CeGaT RNA Fusion Panel is a targeted RNA sequencing solution designed to detect both known and novel gene fusions across 160 genes associated with over 30 cancer types, enhancing cancer and precision medicine research.

Twist Exome 2.0 is a comprehensive exome sequencing panel designed to detect rare and inherited diseases, as well as germline cancers. Its high uniformity and low off-target rate deliver best-in-class sequencing efficiency, enabling quality data collection with less sequencing.

For best-in-class results, use best-in-class tools

Delivers excellent uniformity and increased on-target rates

The Twist Standard Hybridization Reagent Kit v2 is the gold standard for efficient and specific binding of panel probes to your regions of interest. Coupled with Twist’s Catalog or Custom Panels, this standard hybridization workflow provides the optimal conditions for a broad range of content.

Enables sequencing of genes that are difficult or impossible to fully sequence with short read technology. 

Focus on important genes in pharmacogenomics that are critical to drug metabolism and patient therapeutic response.

Twist Diversity SNP Panel gives researchers a new flexible ethnicity-neutral gold standard to use for GBS

Deep coverage of clinically focused targets that allow for the study of methylation patterns that may be relevant to early cancer detection and diagnosis from tumor and liquid biopsy samples.

Streamline the identification of heritable disease-linked alleles, be it through carrier screening or pre- and post-natal testing.

The Twist Alliance Clinical Research Exome helps support the Broad Institute Genomics Platform and was designed using validated data from clinical patient samples.

The Twist Alliance Canine Exome developed in collaboration with the Broad Institute

The Twist Alliance CNTG Exome - 41 MB provides highly uniform coverage of the entire exome as well as full coverage of the mitochondrial genome.

Coverage of rare disease-associated genes 

Coverage of 72 selected cancer-associated genes

The Twist Respiratory Virus Research Panel enables comprehensive detection and sequencing of 29 common respiratory viruses, allowing researchers to identify pathogens and analyze their genomes.

Fast and Easy Library Workflows

Twist's RNA Sequencing Solutions provide comprehensive next-generation sequencing (NGS) workflows, offering both targeted and whole transcriptome approaches to generate uniform, high-quality RNA sequencing libraries from diverse sample types.

The Twist RNA Exome offers a comprehensive solution for capturing human protein-coding regions, enabling efficient transcriptome analysis, isoform study, and fusion detection with high sensitivity and specificity.

The Twist NGS Methylation Detection System provides a robust, end-to-end sample preparation solution for identifying methylated regions in the human genome. The workflow employs a unique enzymatic process from New England Biolabs® that is much less damaging to DNA, alongside Twist‘s Custom Methylation Panel design.

The Twist Bioscience MRD Rapid 500 Panel is a scalable target enrichment solution for monitoring minimal residual disease that leverages Twist’s silicon based DNA synthesis platform to design and manufacture capture panels for personalized medicine. 

The Twist UMI Adapter System enhances the detection of low-frequency somatic variants in cell-free DNA (cfDNA) by incorporating unique molecular identifiers (UMIs) during library preparation, increasing sensitivity and reducing PCR errors.

An expanding portfolio of NGS panels for research into haematological and solid tumour cancers, as well as library preparation kits for the accurate detection of a wide range of genetic aberrations

The SureSeq™ Myeloid Plus NGS Complete Workflow combines the rapid Universal NGS Workflow hybridisation-based target enrichment method together with OGT’s expert bait design to detect 49 key genes implicated in myeloid disorders.