Drug discovery > Target Discovery Products & Reviews

Streamline the identification of heritable disease-linked alleles, be it through carrier screening or pre- and post-natal testing.

The Twist Alliance Clinical Research Exome helps support the Broad Institute Genomics Platform and was designed using validated data from clinical patient samples.

The Twist Alliance Canine Exome developed in collaboration with the Broad Institute

The Twist Alliance CNTG Exome - 41 MB provides highly uniform coverage of the entire exome as well as full coverage of the mitochondrial genome.

Coverage of rare disease-associated genes 

Coverage of 72 selected cancer-associated genes

The Twist Respiratory Virus Research Panel enables comprehensive detection and sequencing of 29 common respiratory viruses, allowing researchers to identify pathogens and analyze their genomes.

Fast and Easy Library Workflows

Twist's RNA Sequencing Solutions provide comprehensive next-generation sequencing (NGS) workflows, offering both targeted and whole transcriptome approaches to generate uniform, high-quality RNA sequencing libraries from diverse sample types.

The Twist RNA Exome offers a comprehensive solution for capturing human protein-coding regions, enabling efficient transcriptome analysis, isoform study, and fusion detection with high sensitivity and specificity.

The Twist NGS Methylation Detection System provides a robust, end-to-end sample preparation solution for identifying methylated regions in the human genome. The workflow employs a unique enzymatic process from New England Biolabs® that is much less damaging to DNA, alongside Twist‘s Custom Methylation Panel design.

The Twist Bioscience MRD Rapid 500 Panel is a scalable target enrichment solution for monitoring minimal residual disease that leverages Twist’s silicon based DNA synthesis platform to design and manufacture capture panels for personalized medicine. 

The Twist UMI Adapter System enhances the detection of low-frequency somatic variants in cell-free DNA (cfDNA) by incorporating unique molecular identifiers (UMIs) during library preparation, increasing sensitivity and reducing PCR errors.

Twist's cfDNA Pan-Cancer Reference Standard v2 provides researchers with high-quality, synthetic reference materials to assess and validate liquid biopsy assays, enhancing the detection of low-frequency cancer associated variants.

Flare™ is a ligand-based and structure-based drug design platform. Through high-resolution 3D visualization and in-depth analysis of target structures and potential ligands, Flare enables users to optimize and prioritize new molecules efficiently and effectively.

Flare™ enables the production of high-resolution 3D graphics of your ligands and proteins for publications and communication of results.

Flare™ FEP enables research chemists to refine docking results, making the right structure-based design choices for lead optimization with confidence.

Spark™ is a powerful scaffold hopping and bioisosteric replacement solution that generates highly innovative ideas for your project to explore chemical space and escape IP and toxicity traps.

Blaze™ is an advanced virtual screening platform enabling you to dramatically increase your wet screening hit rate at a fraction of the cost.

Cresset Discovery is a premier computational chemistry CRO with a proven track record delivering high impact drug discovery projects. From ideation to synthesis and biological results, their expert CADD scientists are the best at what they do. Working alongside you from the ground up, they apply the best in silico techniques, and give expert advice and guidance, to accelerate your assets through the pipeline.

Cyto-Surf® A is required to operate Cyto-Mine®. It provides the oil phase of our water-in-oil picodroplet system and is fully optimized for use with Cyto-Mine®.

Cyto-Surf® B is required to operate Cyto-Mine®. It provides the surfactant necessary to make stable biocompatible picodroplets and is fully optimized for Cyto-Mine®.

Cyto-Cartridge® provides the core microfluidic functions used by Cyto-Mine® to implement picodroplet workflows. It is a single-use, fully disposable device to ensure zero cross-contamination between runs and maintain cell quality.

Pico-Break™ is used to gently reduce the stability of picodroplets in order to release cellular or molecular contents into an aqueous medium for subsequent processing.

The PrismA ELISA kit is an enzyme-linked immunosorbent assay designed to measure residual ligand leakage when using MabSelect PrismA ™ chromatography resin and Fibro ™ PrismA chromatography adsorbers. The kit is used during the development and manufacture of monoclonal antibody (mAb) biopharmaceuticals.